Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile
and promising motif in drug design and medicinal chemistry. Herein, we discuss the current …

The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …

In this present work, the newly synthesized compound E)-N'-(5-bromo-2-
hydroxybenzylidene) isonicotinohydrazide (2) has been synthesized and characterized by …

Highlights•Computational filters for unspecific and promiscuous compounds are being
disseminated in the literature.•Apparent promiscuity of certain chemical scaffolds does not …

Compounds with acylhydrazone fragments contain amide and imine groups that can act as
electron donors and acceptors, so they are easier to bind to biological targets and thus …

Abstract The oncogenic Epstein–Barr virus (EBV) evades the immune system through
limiting the expression of its highly antigenic and essential genome maintenance protein …

A novel bipyridine Schiff base ligand C 12 H 9 ClN 4 O (HL) and its two transition metal
complexes [CoL 2] NO 3⋅ H 2 O (1) and CuL 2⋅ CH 3 OH (2) have been synthesized. Their …

A new crystal, ie,(E)-5-methyl-N′-(pyridin-2-ylmethylene)-1H-pyrazole-3-carbohydrazide (E-
MPPC) has been synthesized and characterized by using FT-IR, UV-Vis, 1 H-NMR, 13 C …

The acylhydrazone unit is well represented in screening databases used to find ligands for
biological targets, and numerous bioactive acylhydrazones have been reported. However …

(Nitrophenyl) hydrazone derivatives of N-acylhydrazone were synthesized and screened for
suppress lymphocyte proliferation and nitrite inhibition in macrophages. Compared to an …