Bystander T cells in cancer immunology and therapy
SL Meier, AT Satpathy, DK Wells - Nature Cancer, 2022 - nature.com
Cancer-specific T cells are required for effective anti-cancer immunity and have a central
role in cancer immunotherapy. However, emerging evidence suggests that only a small …
role in cancer immunotherapy. However, emerging evidence suggests that only a small …
Natural killer cells: from innate to adaptive features
AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D–NKG2DL axis
EC Lerner, KI Woroniecka, VM D'Anniballe… - Nature Cancer, 2023 - nature.com
The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell
killing by CD8+ T cells recognizing cognate antigens presented in the context of target cell …
killing by CD8+ T cells recognizing cognate antigens presented in the context of target cell …
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from
stochastic dropout and characteristic bimodal expression distributions in which expression is …
stochastic dropout and characteristic bimodal expression distributions in which expression is …
KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity
D Herndler-Brandstetter, H Ishigame, R Shinnakasu… - Immunity, 2018 - cell.com
Protective immunity against pathogens depends on the efficient generation of functionally
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …
Significance of bystander T cell activation in microbial infection
During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …
infecting pathogens can be activated by cytokines without cognate antigens, termed …
The activation of bystander CD8+ T cells and their roles in viral infection
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
Bystander activation and autoimmunity
The interaction over time of genetic, epigenetic and environmental factors (ie, autoimmune
ecology) increases or decreases the liability an individual would have to develop an …
ecology) increases or decreases the liability an individual would have to develop an …
A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity
Virtual memory T (TVM) cells are a T cell subtype with a memory phenotype but no prior
exposure to foreign antigen. Although TVM cells have antiviral and antibacterial functions …
exposure to foreign antigen. Although TVM cells have antiviral and antibacterial functions …
Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool
M von Hoesslin, M Kuhlmann, GP de Almeida… - Science …, 2022 - science.org
Resident T lymphocytes (TRM) protect tissues during pathogen reexposure. Although TRM
phenotype and restricted migratory pattern are established, we have a limited understanding …
phenotype and restricted migratory pattern are established, we have a limited understanding …