The integrity and permeability of epithelial and endothelial barriers depend on the formation
of tight junctions, adherens junctions, and a junction-associated cytoskeleton. The …

Background Disrupted protein homeostasis (proteostasis) has been demonstrated to
facilitate the progression of various diseases. The cytosolic T‐complex protein‐1 ring …

Background Biomarkers that reflect glioblastoma tumour activity and treatment response are
urgently needed to help guide clinical management, particularly for recurrent disease. As the …

The physical interactome of a protein can be altered upon perturbation, modulating cell
physiology and contributing to disease. Identifying interactome differences of normal and …

Chaperonin containing TCP1 (CCT/TRiC) is a multi-subunit protein folding complex that
enables the cancer phenotype to emerge from the mutational landscape that drives …

Protein synthesis from mRNA is an energy-intensive and strictly controlled biological
process. Translation elongation is a well-coordinated and multifactorial step in translation …

BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and
homologs have been identified in plants. The protein is expressed ubiquitously but is most …

Aryl hydrocarbon receptor (AHR) is a ligand-dependent receptor that belongs to the
superfamily of basic helix-loop-helix (bHLH) transcription factors. The activation of the …

Molecular chaperones are highly conserved across evolution and play a crucial role in
preserving protein homeostasis. The 60 kDa heat shock protein (HSP60), also referred to as …

The human Usher syndrome (USH) is the most common form of a sensory hereditary
ciliopathy characterized by progressive vision and hearing loss. Mutations in the genes …