[HTML][HTML] Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans
B Hwa Yun, J Guo, M Bellamri… - Mass spectrometry …, 2020 - Wiley Online Library
Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
[HTML][HTML] Recent studies on DNA adducts resulting from human exposure to tobacco smoke
B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …
smokers and are proposed as being potential biomarkers of cancer risk. We have …
[HTML][HTML] Emerging technologies in mass spectrometry-based DNA adductomics
J Guo, RJ Turesky - High-throughput, 2019 - mdpi.com
The measurement of DNA adducts, the covalent modifications of DNA upon the exposure to
the environmental and dietary genotoxicants and endogenously produced electrophiles …
the environmental and dietary genotoxicants and endogenously produced electrophiles …
Identification of formaldehyde-induced DNA–RNA cross-links in the A/J mouse lung tumorigenesis model
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
tobacco products, and exposure to it is likely one of the factors contributing to the …
tobacco products, and exposure to it is likely one of the factors contributing to the …
[HTML][HTML] Size-and stereochemistry-dependent transcriptional bypass of DNA alkyl phosphotriester adducts in mammalian cells
Environmental, endogenous and therapeutic alkylating agents can react with internucleotide
phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are …
phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are …
Cytotoxic and mutagenic properties of alkyl phosphotriester lesions in Escherichia coli cells
Exposure to many endogenous and exogenous agents can give rise to DNA alkylation,
which constitutes a major type of DNA damage. Among the DNA alkylation products, alkyl …
which constitutes a major type of DNA damage. Among the DNA alkylation products, alkyl …
Quantification of DNA Lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in mammalian cells
Quantitative measurement of DNA adducts in carcinogen-exposed cells provides the
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
Replication Studies of Alkyl Phosphotriester Lesions in Human Cells
Alkyl phosphotriester (alkyl-PTE) lesions in DNA are shown to be poorly repaired; however,
little is known about how these lesions impact DNA replication in human cells. Here, we …
little is known about how these lesions impact DNA replication in human cells. Here, we …
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine
The tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …