Leveraging transformers‐based language models in proteome bioinformatics
NQK Le - Proteomics, 2023 - Wiley Online Library
In recent years, the rapid growth of biological data has increased interest in using
bioinformatics to analyze and interpret this data. Proteomics, which studies the structure …
bioinformatics to analyze and interpret this data. Proteomics, which studies the structure …
Deep learning tools to accelerate antibiotic discovery
Introduction As machine learning (ML) and artificial intelligence (AI) expand to many
segments of our society, they are increasingly being used for drug discovery. Recent deep …
segments of our society, they are increasingly being used for drug discovery. Recent deep …
Artificial intelligence-driven antimicrobial peptide discovery
P Szymczak, E Szczurek - Current Opinion in Structural Biology, 2023 - Elsevier
Antimicrobial peptides (AMPs) emerge as promising agents against antimicrobial resistance,
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …
Machine learning for antimicrobial peptide identification and design
Artificial intelligence (AI) and machine learning (ML) models are being deployed in many
domains of society and have recently reached the field of drug discovery. Given the …
domains of society and have recently reached the field of drug discovery. Given the …
Deep learning for advancing peptide drug development: Tools and methods in structure prediction and design
X Wu, H Lin, R Bai, H Duan - European Journal of Medicinal Chemistry, 2024 - Elsevier
Peptides can bind challenging disease targets with high affinity and specificity, offering
enormous opportunities for addressing unmet medical needs. However, peptides' unique …
enormous opportunities for addressing unmet medical needs. However, peptides' unique …
iAMP-Attenpred: a novel antimicrobial peptide predictor based on BERT feature extraction method and CNN-BiLSTM-Attention combination model
W Xing, J Zhang, C Li, Y Huo… - Briefings in …, 2024 - academic.oup.com
As a kind of small molecule protein that can fight against various microorganisms in nature,
antimicrobial peptides (AMPs) play an indispensable role in maintaining the health of …
antimicrobial peptides (AMPs) play an indispensable role in maintaining the health of …
Diff-AMP: tailored designed antimicrobial peptide framework with all-in-one generation, identification, prediction and optimization
R Wang, T Wang, L Zhuo, J Wei, X Fu… - Briefings in …, 2024 - academic.oup.com
Antimicrobial peptides (AMPs), short peptides with diverse functions, effectively target and
combat various organisms. The widespread misuse of chemical antibiotics has led to …
combat various organisms. The widespread misuse of chemical antibiotics has led to …
Using the local symmetry in amino acids sequences of polypeptides to improve the predictive potential of models of their inhibitor activity
AP Toropova, AA Toropov - Amino Acids, 2023 - Springer
The minimal inhibitory concentrations (pMIC) are a valuable measure of the biological
activity of polypeptides. Numerical data on the pMIC are necessary to systematize …
activity of polypeptides. Numerical data on the pMIC are necessary to systematize …
[HTML][HTML] Classification of bioactive peptides: A systematic benchmark of models and encodings
Bioactive peptides are short amino acid chains possessing biological activity and exerting
physiological effects relevant to human health. Despite their therapeutic value, their …
physiological effects relevant to human health. Despite their therapeutic value, their …
Identifying and characterization of novel broad-spectrum bacteriocins from the Shanxi aged vinegar microbiome: Machine learning, molecular simulation, and activity …
M Cui, M Wang, H Sun, L Yu, Z Su, X Zhang… - International Journal of …, 2024 - Elsevier
Shanxi aged vinegar microbiome encodes a wide variety of bacteriocins. The aim of this
study was to mine, screen and characterize novel broad-spectrum bacteriocins from the …
study was to mine, screen and characterize novel broad-spectrum bacteriocins from the …