To evaluate the effects of long-term, high-dose exposure to thrombopoietin (TPO), lethally
irradiated mice were grafted with bone marrow cells infected with a retrovirus carrying the …

A new factor-independent megakaryoblastic cell line, designated SET-2, was established
from the peripheral blood of a patient with leukemic transformation of essential …

In this report a sensitive enzyme-linked immunosorbent assay (ELISA) for the measurement
of plasma thrombopoietin (Tpo) is described that is solely based on monoclonal antibodies …

Thrombopoietin (TPO) is a ligand for c‐mpl that promotes both proliferation and
differentiation of megakaryocytes in vivo and in vitro. We investigated the expression of c …

Thrombopoietin (TPO) is implicated as a primary regulator of megakaryopoiesis and
thrombopoiesis. However, the biologic effects of TPO on human acute myeloblastic …

Thrombocytopenia is a frequent feature of myelodysplastic syndromes (MDS) that could be
improved by the use of recombinant human megakaryocyte growth and development factor …

The gene for the thrombopoietin receptor, c-mpl, has been shown to be overexpressed at
the mRNA level in acute myeloid leukemia (AML) and myelodysplastic syndrome. A recent …

Human thrombopoietin (TPO) is a haemopoietic growth factor that is essential for the growth
and development of megakaryocytes. However, c‐Mpl, the TPO receptor, has been detected …

Thrombopoietin (TPO) regulates megakaryocytic (MK) maturation and platelet production.
Molecular and cellular mechanisms of the TPO-induced MK differentiation are not totally …

BACKGROUND Chronic myelogenous leukemia (CML) represents a paradigm of the
stepwise increment in disease aggressiveness, resistance to therapy, and transformation …