Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Spatially resolved omics technologies are transforming our understanding of biological
tissues. However, the handling of uni-and multimodal spatial omics datasets remains a …

Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …

Spatial clustering, which shares an analogy with single-cell clustering, has expanded the
scope of tissue physiology studies from cell-centroid to structure-centroid with spatially …

Adaptive therapy is a dynamic cancer treatment protocol that updates (or 'adapts') treatment
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …

Tumors are complex and heterogeneous diseases characterized by an intricate milieu and
dynamically in connection with surrounding and distant tissues. In the last decades, great …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant
transcriptional heterogeneity, intercellular communication, and organization of …

In this study, we explore the dynamic process of colorectal cancer progression, emphasizing
the evolution toward a more metastatic phenotype. The term" evolution" as used in this study …