Low oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus
that metazoan organisms have contended with since they evolved from their single-celled …

Although modern techniques such as two-photon microscopy can now provide cellular-level
three-dimensional imaging of the intact living brain, the speed and fields of view of these …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and
hypovascularization, resulting in significant intratumoral hypoxia (low oxygen) that …

Normal mitochondrial function is a critical factor in maintaining cellular homeostasis in
various organs of the body. Due to the involvement of mitochondrial dysfunction in many …

Laser‐induced fluorescence (LIF) of colonic tissue was examined both in vitro and in vivo to
assess the ability of the technique to distinguish neoplastic from hyperplastic and normal …

The number of parameters (ie, EEG or ICP-intracranial pressure) routinely monitored under
clinical situations is limited. The brain function analyzer described in this paper enables …

The naturally occurring autofluorescence of cells and tissues is based on biomolecules
containing intrinsic fluorophores, such as porphyrins, the amino acids tryptophan and …

Hypoxia is one of the features of poorly vascularised areas of solid tumours but cancer cells
can survive in these areas despite the low oxygen tension. The adaptation to hypoxia …

Precise time-and space-resolved measurement of brain energy metabolism and circulation
in vivo would provide important information on the cerebral physiology and pathophysiology …

Ischemic cerebral stroke is one of the leading causes of death and disability in humans.
However, molecular processes underlying the development of this pathology remain poorly …