Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

Context Obesity is responsible for an increased risk of sub-fecundity and infertility. Obese
women show poorer reproductive outcomes regardless of the mode of conception, and …

Recently, nutraceutical bioactive compounds in foods have been discovered for their
potential health benefits regarding the prevention of chronic disorders, such as cancer, and …

The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …

The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Emerging evidence indicates that the accretion of senescent cells is linked to metabolic
disorders. However, the underlying mechanisms and metabolic consequences of cellular …

Abstract Background The Obesity Medicine Association (OMA) Clinical Practice Statement
(CPS) regarding definition, diagnosis, bias, standard operating procedures (SOPs) and …