The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective

P Mammadzada, PM Corredoira, H André - Cellular and Molecular Life …, 2020 - Springer
Understanding the mechanisms that underlie age-related macular degeneration (AMD) has
led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have …

Luteolin Alleviates Epithelial‐Mesenchymal Transformation Induced by Oxidative Injury in ARPE‐19 Cell via Nrf2 and AKT/GSK‐3β Pathway

L Chen, Y Zhu, J Zhou, R Wu, N Yang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Oxidative stress plays a critical role in age‐related macular degeneration (AMD), and
epithelial‐mesenchymal transition (EMT) is involved in this process. The aim of this study …

Novel programmed cell death as therapeutic targets in age-related macular degeneration?

M Yang, KF So, WC Lam, ACY Lo - International Journal of Molecular …, 2020 - mdpi.com
Age-related macular degeneration (AMD) is a leading cause of severe visual loss among
the elderly. AMD patients are tormented by progressive central blurring/loss of vision and …

[HTML][HTML] The phenotypic course of age-related macular degeneration for ARMS2/HTRA1: the EYE-RISK consortium

EF Thee, JM Colijn, A Cougnard-Grégoire… - Ophthalmology, 2022 - Elsevier
Purpose Age-related maculopathy susceptibility 2 (ARMS2) is considered the most
enigmatic of the genes for age-related macular degeneration (AMD). We investigated the …

[HTML][HTML] Development of a genotype assay for age-related macular degeneration: the EYE-RISK Consortium

A de Breuk, IE Acar, E Kersten, MM Schijvenaars… - Ophthalmology, 2021 - Elsevier
Purpose To develop a genotype assay to assess associations with common and rare age-
related macular degeneration (AMD) risk variants, to calculate an overall genetic risk score …

The changing landscape for the management of patients with neovascular AMD: brolucizumab in clinical practice

I Pearce, W Amoaku, C Bailey, L Downey, R Gale… - Eye, 2022 - nature.com
Untreated neovascular age-related macular degeneration (nAMD) can lead to severe and
permanent visual impairment. The chronic nature of the disease can have a significant …

Impact on visual acuity in neovascular age related macular degeneration (nAMD) in Europe due to COVID-19 pandemic lockdown

C Arruabarrena, MD Toro, M Onen… - Journal of clinical …, 2021 - mdpi.com
This is a retrospective, multicenter study of consecutive patients with nAMD scheduled for a
visit and/or a treatment with an intravitreal injection (IVI) during the 3 months before …

Association of vision-related quality of life with visual function in age-related macular degeneration

SG Pondorfer, JH Terheyden, M Heinemann… - Scientific reports, 2019 - nature.com
The purpose of this study was to assess which visual function measures are most strongly
associated with vision-related quality of life (VRQoL) in age-related macular degeneration …

Interactions between apolipoprotein E metabolism and retinal inflammation in age-related macular degeneration

ML Hu, J Quinn, K Xue - Life, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a multifactorial retinal disorder that is a major
global cause of severe visual impairment. The development of an effective therapy to treat …

Intake of vegetables, fruit, and fish is beneficial for age-related macular degeneration

APM de Koning-Backus, GHS Buitendijk… - American journal of …, 2019 - Elsevier
Purpose What patients should eat to reduce their risk of age-related macular degeneration
(AMD) is still unclear. We investigated the effect of a diet recommended by Health Councils …