[HTML][HTML] Neovascular progression and retinal dysfunction in the laser-induced choroidal neovascularization mouse model

A Salas, A Badia, L Fontrodona, M Zapata… - Biomedicines, 2023 - mdpi.com
The mouse model of laser-induced choroidal neovascularization (LI-CNV) has been widely
used to study neovascular age-related macular degeneration; however, it still lacks a …

[HTML][HTML] Machine learning-based automated detection and quantification of geographic atrophy and hypertransmission defects using spectral domain optical …

G Kalra, H Cetin, J Whitney, S Yordi, Y Cakir… - Journal of Personalized …, 2022 - mdpi.com
The current study describes the development and assessment of innovative, machine
learning (ML)-based approaches for automated detection and pixel-accurate measurements …

Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

MM Mauschitz, T Verzijden, AK Schuster… - British Journal of …, 2023 - bjo.bmj.com
Background/aims To investigate the association of commonly used systemic medications
with prevalent age-related macular degeneration (AMD) in the general population. Methods …

[HTML][HTML] DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration

T Mathis, F Baudin, AS Mariet, S Augustin… - The Journal of clinical …, 2024 - jci.org
Neovascular age-related macular degeneration (nAMD) remains a major cause of visual
impairment and puts considerable burden on patients and health care systems. l-DOPA …

[HTML][HTML] Genotype-and phenotype-based subgroups in geographic atrophy secondary to age-related macular degeneration: the EYE-RISK Consortium

M Biarnés, JM Colijn, J Sousa, LL Ferraro, M Garcia… - Ophthalmology …, 2020 - Elsevier
Purpose Geographic atrophy (GA) secondary to age-related macular degeneration is
considered a single entity. This study aimed to determine whether GA subgroups exist that …

[HTML][HTML] Monitoring for neovascular age-related macular degeneration (AMD) reactivation at home: the MONARCH study

E Ward, RA Wickens, A O'Connell, LA Culliford… - Eye, 2021 - nature.com
Aims This study aims to quantify the diagnostic test-accuracy of three visual function self-
monitoring tests for detection of active disease in patients with neovascular age-related …

[HTML][HTML] Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration developing novel clinical endpoints for interventional …

JH Terheyden, FG Holz, S Schmitz-Valckenberg… - Trials, 2020 - Springer
Background There is an unmet need for treatment options in intermediate age-related
macular degeneration (iAMD). However, for any new interventions to be tested in clinical …

[HTML][HTML] Detecting vision loss in intermediate age-related macular degeneration: a comparison of visual function tests

SG Pondorfer, M Heinemann, MWM Wintergerst… - PLoS …, 2020 - journals.plos.org
The purpose of the study was to evaluate the diagnostic accuracy of visual function tests in
intermediate age-related macular degeneration (iAMD). A total of 62 subjects (38 patients …

Clinical role of epigenetics and network analysis in eye diseases: a translational science review

M Lanza, G Benincasa, D Costa… - Journal of …, 2019 - Wiley Online Library
Network medicine is a molecular‐bioinformatic approach analyzing gene‐gene interactions
that can perturb the human interactome. This review focuses on epigenetic changes …

Association of genetic variants with response to anti–vascular endothelial growth factor therapy in age-related macular degeneration

L Lorés-Motta, M Riaz, M Grunin… - JAMA …, 2018 - jamanetwork.com
Importance Visual acuity (VA) outcomes differ considerably among patients with
neovascular age-related macular degeneration (nAMD) treated with anti–vascular …