Inflammation is a physiological response to aggression of pathogenic agents aimed at
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …

Cardiac transplantation remains the gold standard in the treatment of advanced heart failure.
With advances in immunosuppression, long-term outcomes continue to improve despite …

Background Cardiovascular disease had a global prevalence of 523 million cases and 18.6
million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is …

Data from clinical research and our previous study have suggested the potential
involvement of SENP1, the major protease of post-translational SUMOylation, in …

Despite much progress in improving graft outcome during cardiac transplantation, chronic
allograft vasculopathy (CAV) remains an impediment to long-term graft survival. MicroRNAs …

Cardiac allograft vasculopathy (CAV) is a coronary artery disease affecting 50% of heart
transplant (HTx) recipients, and it is the major cause of graft loss. CAV is driven by the …

Background Mesenchymal stem cell (MSC) transplantation shows promise for treating
transplant arteriosclerosis, at least partly via promoting endothelial regeneration. However …

Complement is a major contributor to inflammation and graft injury. This system is especially
important in ischemiareperfusion injury/delayed graft function as well as in acute and …

Background The gut microbiota influences many immunological processes but how its
disruption affects transplant rejection is poorly understood. Methods Interposition grafting of …

HLA antibodies play a major role in the recipient's immune response against the renal
allograft and are an established risk factor for antibody-mediated rejection and subsequent …