Mitochondrial complex I as a pathologic and therapeutic target for Parkinson's disease
KP Tryphena, US Nikhil, P Pinjala… - ACS Chemical …, 2023 - ACS Publications
The prevalence of Parkinson's disease (PD) continues to increase despite substantial
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …
[HTML][HTML] Gallic acid and neurodegenerative diseases
TO Obafemi, BE Ekundayo, OB Adewale, BA Afolabi… - Phytomedicine Plus, 2023 - Elsevier
Backgound Gallic acid (GA) is a polyphenolic substance which can be sourced naturally
from plant sources and can also be synthesized industrially. In-depth study on GA in recent …
from plant sources and can also be synthesized industrially. In-depth study on GA in recent …
Machine learning modeling and insights into the structural characteristics of drug-induced neurotoxicity
X Zhao, Y Sun, R Zhang, Z Chen, Y Hua… - Journal of Chemical …, 2022 - ACS Publications
Neurotoxicity can be resulted from many diverse clinical drugs, which has been a cause of
concern to human populations across the world. The detection of drug-induced neurotoxicity …
concern to human populations across the world. The detection of drug-induced neurotoxicity …
Nuclear DNA and Mitochondrial Damage of the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Human Neuroblastoma Cells
M Bellamri, K Brandt, K Cammerrer… - Chemical research in …, 2023 - ACS Publications
Animal fat and iron-rich diets are risk factors for Parkinson's disease (PD). The heterocyclic
aromatic amines (HAAs) harman and norharman are neurotoxicants formed in many foods …
aromatic amines (HAAs) harman and norharman are neurotoxicants formed in many foods …
Initial Molecular Mechanisms of the Pathogenesis of Parkinson's Disease in a Mouse Neurotoxic Model of the Earliest Preclinical Stage of This Disease
A Kolacheva, E Pavlova, A Bannikova… - International Journal of …, 2024 - mdpi.com
Studying the initial molecular mechanisms of the pathogenesis of Parkinson's disease (PD),
primarily in the nigrostriatal dopaminergic system, is one of the priorities in neurology. Of …
primarily in the nigrostriatal dopaminergic system, is one of the priorities in neurology. Of …
IDO1, FAT10, IFI6, and GILT are involved in the antiretroviral activity of γ-interferon and IDO1 restricts retrovirus infection by autophagy enhancement
Gamma-interferon (γ-IFN) significantly inhibits infection by replication-defective viral vectors
derived from the human immunodeficiency virus type 1 (HIV-1) or murine leukemia virus …
derived from the human immunodeficiency virus type 1 (HIV-1) or murine leukemia virus …
Fluorescence microscopy-based sensitive method to quantify dopaminergic neurodegeneration in a Drosophila model of Parkinson's disease
M Ayajuddin, R Chaurasia, A Das, P Modi… - Frontiers in …, 2023 - frontiersin.org
Death of dopaminergic (DAergic) neurons in the substantia nigra pars compacta of the
human brain is the characteristic pathological feature of Parkinson's disease (PD). On …
human brain is the characteristic pathological feature of Parkinson's disease (PD). On …
Association between aldehyde exposure and sex steroid hormones among adults
W Xing, W Gu, M Liang, Z Wang, D Fan… - … Science and Pollution …, 2023 - Springer
Exogenous and endogenous exposure to aldehydes is seen worldwide. Aldehydes are
closely associated with human diseases, especially reproductive toxicity. However, the effect …
closely associated with human diseases, especially reproductive toxicity. However, the effect …
Neuroprotection of Kaji-Ichigoside F1 via the BDNF/Akt/mTOR Signaling Pathways against NMDA-Induced Neurotoxicity
F Chen, L Wang, F Jin, L Li, T Wang, M Gao… - International Journal of …, 2022 - mdpi.com
Kaji-ichigoside F1 (KF1), a natural oleanane-type triterpenoid saponin, is the main active
constituent from Rosa roxburghii. In the southwest regions of China, particularly in Guizhou …
constituent from Rosa roxburghii. In the southwest regions of China, particularly in Guizhou …
The alcohol flushing response is associated with the risk of depression
The alcohol flushing response is experienced by 36–45% of East Asians after they consume
a small amount of alcohol. Because individuals with this response are unable to metabolize …
a small amount of alcohol. Because individuals with this response are unable to metabolize …