Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Fungi do not show the same pattern of organismal birth and death shown by animals. For
one thing, the concept of organism is not as clear in fungi as it is in animals and plants. The …

Depressed patients often do not respond to the first antidepressant prescribed, resulting in
sequential trials of different medications. Personalised medicine offers a means of reducing …

Background: Individuals with major depressive disorder (MDD) vary in their response to
antidepressants. However, identifying objective biomarkers, prior to or early in the course of …

Antidepressants must be taken for weeks before response can be assessed with many
patients not responding to the first medication prescribed. This often results in long delays …

Drawing on dynamical systems theory, we investigated whether within-persons-detected
early-warning signals in momentary affect preceded critical transitions toward lower levels of …

Aims Electroacupuncture (EA) shows advantages in both clinical practice and depression
animal models. Dopaminergic‐related dysfunction in the prefrontal cortex (PFC) may be a …

Treatment outcomes for major depressive disorder (MDD) need to be improved. Presently,
no clinically relevant tools have been established for stratifying subgroups or predicting …

Background Course of illness in major depression (MD) is highly varied, which might lead to
both under-and overtreatment if clinicians adhere to a'one-size-fits-all'approach. Novel …