[HTML][HTML] The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

L Zheng, Z Zhang, P Sheng, A Mobasheri - Ageing research reviews, 2021 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

[HTML][HTML] NF-κB signaling pathways in osteoarthritic cartilage destruction

MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

[HTML][HTML] Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression

Y Miao, Y Chen, F Xue, K Liu, B Zhu, J Gao, J Yin… - …, 2022 - thelancet.com
Background Osteoarthritis (OA) is the most common joint disease and is the leading cause
of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) …

[HTML][HTML] Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models

Y He, Z Li, PG Alexander, BD Ocasio-Nieves, L Yocum… - Biology, 2020 - mdpi.com
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner

X Zhou, Y Zheng, W Sun, Z Zhang, J Liu… - Cell …, 2021 - Wiley Online Library
Objectives Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐
mannose shows therapeutic value in many inflammatory conditions. Here, we investigated …

Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum

N Fine, S Lively, CA Séguin, AV Perruccio… - Nature Reviews …, 2023 - nature.com
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

Knee osteoarthritis: Current status and research progress in treatment

R Geng, J Li, C Yu, C Zhang… - Experimental and …, 2023 - spandidos-publications.com
Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It is also the
most common form of OA and is characterized by high morbidity and disability rates. With the …

[HTML][HTML] Insights on molecular mechanisms of chondrocytes death in osteoarthritis

E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

[HTML][HTML] Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis

JH Kim, J Jeon, M Shin, Y Won, M Lee, JS Kwak, G Lee… - Cell, 2014 - cell.com
Osteoarthritis (OA), primarily characterized by cartilage degeneration, is caused by an
imbalance between anabolic and catabolic factors. Here, we investigated the role of zinc (Zn …

[HTML][HTML] Bone–cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies

XL Yuan, HY Meng, YC Wang, J Peng, QY Guo… - Osteoarthritis and …, 2014 - Elsevier
Currently, osteoarthritis (OA) is considered a disease of the entire joint, which is not simply a
process of wear and tear but rather abnormal remodelling and joint failure of an organ. The …