The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders

MK Klausen, M Thomsen, G Wortwein… - British Journal of …, 2022 - Wiley Online Library
Drug, alcohol and tobacco use disorders are a global burden affecting millions of people.
Despite decades of research, treatment options are sparse or missing, and relapse rates are …

GLP-1a: going beyond traditional use

LF Laurindo, SM Barbalho, EL Guiguer… - International Journal of …, 2022 - mdpi.com
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon
molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and …

[HTML][HTML] The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

V Chuong, M Farokhnia, S Khom, CL Pince, SK Elvig… - JCI insight, 2023 - ncbi.nlm.nih.gov
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …

Recovery of Bacteroides thetaiotaomicron ameliorates hepatic steatosis in experimental alcohol-related liver disease

M Sangineto, C Grander, F Grabherr, L Mayr… - Gut …, 2022 - Taylor & Francis
Alcohol-related liver disease (ALD) is a major cause of liver disease and represents a global
burden, as treatment options are scarce. Whereas 90% of ethanol abusers develop …

Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4

VR Konanur, TM Hsu, SE Kanoski, MR Hayes… - Physiology & …, 2020 - Elsevier
Phasic dopamine activity is evoked by reliable predictors of food reward and plays a role in
cue-triggered, goal-directed behavior. While this important signal is modulated by …

Use of GLP‐1 receptor agonists and subsequent risk of alcohol‐related events. A nationwide register‐based cohort and self‐controlled case series study

IK Wium‐Andersen, MK Wium‐Andersen… - Basic & Clinical …, 2022 - Wiley Online Library
Animal studies have related glucagon‐like peptide 1 receptor agonists (GLP‐1) to lower
alcohol intake. We examined whether GLP‐1 was associated with risk of alcohol‐related …

The glucagon‐like peptide‐1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post‐mortem brain …

M Farokhnia, BD Browning, ME Crozier… - Addiction …, 2022 - Wiley Online Library
Growing evidence suggests that the glucagon‐like peptide‐1 (GLP‐1) system modulates
alcohol seeking and consumption, and GLP‐1 analogues may represent novel …

Differential association between the GLP1R gene variants and brain functional connectivity according to the severity of alcohol use

M Farokhnia, SJ Fede, EN Grodin, BD Browning… - Scientific reports, 2022 - nature.com
Growing evidence suggests that the glucagon-like peptide-1 (GLP-1) system is involved in
mechanisms underlying alcohol seeking and consumption. Accordingly, the GLP-1 receptor …

Converging vulnerability factors for compulsive food and drug use

KM Serafine, LE O'Dell, EP Zorrilla - Neuropharmacology, 2021 - Elsevier
Highly palatable foods and substance of abuse have intersecting neurobiological, metabolic
and behavioral effects relevant for understanding vulnerability to conditions related to food …

Social media as pharmacovigilance: The potential for patient reports to inform clinical research on glucagon-like peptide 1 (GLP-1) receptor agonists for substance …

MP Bremmer, CS Hendershot - Journal of Studies on Alcohol and Drugs, 2024 - jsad.com
The surge in popularity of semaglutide (Ozempic, Wegovy, Rybelsus) and other glucagon-
like-peptide 1 (GLP-1) receptor agonists has been accompanied by widespread reports of …