Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …

Liver diseases are responsible for global mortality and morbidity and are a significant cause
of death worldwide. Consequently, the advancement of new liver disease targets is of great …

Background & Aims The liver plays crucial roles in the regulation of immune defense during
acute systemic infections. However, the roles of liver cellular clusters and intercellular …

Pancreatic stellate cells (PSC s) play a critical role in fibrogenesis during alcoholic chronic
pancreatitis (ACP). Transforming growth factor‐beta1 (TGF‐β1) is a key regulator of …

Background/Aims: Hepatic stellate cells (HSCs) are the primary cell type responsible for liver
fibrosis. Our study proved that thymosin beta 4 (Tβ4) has anti-fibrogenic effects in HSCs …

Circular RNA (circRNA) has been implicated in liver fibrosis and modulated by multiple
elusive molecular mechanisms, while the effects of N 6-methyladenosine (m 6 A) …

Radiation-induced skin fibrosis is a detrimental and chronic disorder that occurs after
radiation exposure. DNA methylation has been characterized as an important regulatory …

Transforming growth factor-β (TGF-β) plays a central role in hepatic fibrogenesis. This study
investigated the function and mechanism of bone morphogenetic protein-2 (BMP-2) in …

Adiponectin inhibits hepatic stellate cell (HSC) activation and subsequent development of
liver fibrosis via multiple mechanisms. Phosphatase and tensin homolog deletion 10 (PTEN) …

The relationship between alcohol dehydrogenase (ADH) and liver fibrosis has been studied,
but the mechanism of ADH involvement in liver fibrosis remains unclear. The aim of the …