Cold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath
machinery remains unclear. Oxidative stress and autophagy appear to contribute to cold …

Diabetic cardiomyopathy is initiated by alterations in energy substrates. Despite excess of
plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid …

Background Recent evidence has depicted a role of macrophage migration inhibitory factor
(MIF) in cardiac homeostasis under pathological conditions. This study was designed to …

Oxidative stress accelerates adipocyte differentiation and lipid accumulation, leading to
endoplasmic reticulum (ER) stress, which causes insulin resistance. Because …

Aims HIIT (high-intensity interval training) has the potential to reduce cardiometabolic risk
factors, but the effects on cardiac remodeling and local RAS (renin-angiotensin system) in …

Cold stress has been shown to induce the production of reactive oxygen species (ROS),
which can elicit a potentially damaging oxidative burden on cellular metabolism. Here, the …

Mitochondrial oxidative stress is thought to be a key contributor towards the development of
diabetic cardiomyopathy. Thioredoxin 2 (Trx2) is a mitochondrial antioxidant that, along with …

Triphenyltin (TPT) is a widely used pesticide that is highly toxic to a variety of organisms,
including humans, and is a potential contributor to environmental pollution. The present …

Obesity is associated with elevated risk of heart disease. A solid understanding of the safety
and potential adverse effects of high-fat, low-carbohydrate diet (HFLCD) similar to that used …

Background Cardiovascular diseases remain a leading cause of the mortality world-wide,
which is related to several risks, including the life style change and the increased diabetes …