Dry powder inhalers in the digitalization era: current status and future perspectives

S Xiroudaki, A Schoubben, S Giovagnoli, DM Rekkas - Pharmaceutics, 2021 - mdpi.com
During the last decades, the term “drug delivery systems”(DDSs) has almost fully replaced
previously used terms, such as “dosage forms”, in an attempt to emphasize the importance …

Spray-dried inhalable powder formulations of therapeutic proteins and peptides

BB Eedara, W Alabsi, D Encinas-Basurto, R Polt… - AAPS …, 2021 - Springer
Respiratory diseases are among the leading causes of morbidity and mortality worldwide.
Innovations in biochemical engineering and understanding of the pathophysiology of …

Advances in pulmonary drug delivery devices for the treatment of chronic obstructive pulmonary disease

M Cazzola, F Cavalli, OS Usmani… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction Proper device selection is crucial for the clinical results of inhalation therapy.
However, none of the available devices fully conforms to the requirements for delivering …

Liposomes or extracellular vesicles: a comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery

A Al-Jipouri, SH Almurisi, K Al-Japairai, LM Bakar… - Polymers, 2023 - mdpi.com
The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention
compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and …

[HTML][HTML] Pulmonary inhalation for disease treatment: Basic research and clinical translations

B Wang, L Wang, Q Yang, Y Zhang, T Qinglai, X Yang… - Materials Today Bio, 2024 - Elsevier
Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with
few systemic side effects. In addition, it is non-invasive and has good patient compliance …

Recent developments in the computational simulation of dry powder inhalers

J Capecelatro, W Longest, C Boerman… - Advanced Drug Delivery …, 2022 - Elsevier
This article reviews recent developments in computational modeling of dry powder inhalers
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …

[HTML][HTML] Alginate aerogels by spray gelation for enhanced pulmonary delivery and solubilization of beclomethasone dipropionate

T Duong, M Vivero-Lopez, I Ardao… - Chemical Engineering …, 2024 - Elsevier
Aerogel technology is an emerging platform that offers alternative and cost-effective dry
carriers with advanced performances for the pharmaceutical industry. The innovative …

Recent advances in the development of microparticles for pulmonary administration

H Jain, A Bairagi, S Srivastava, SB Singh… - Drug discovery today, 2020 - Elsevier
Highlights•The pulmonary route is an efficient route for respiratory diseases.•Technosphere
® and PulmoSphere™ are novel inhalable technologies for drug delivery.•Microparticles are …

Drug delivery applications of three-dimensional printed (3DP) mesoporous scaffolds

T Limongi, F Susa, M Allione, E Di Fabrizio - Pharmaceutics, 2020 - mdpi.com
Mesoporous materials are structures characterized by a well-ordered large pore system with
uniform porous dimensions ranging between 2 and 50 nm. Typical samples are zeolite …

A pathway from porous particle technology toward tailoring aerogels for pulmonary drug administration

T Duong, C López-Iglesias, PK Szewczyk… - … in Bioengineering and …, 2021 - frontiersin.org
Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry
powder inhalers (DPIs) are convenient, portable and environmentally friendly devices …