Modelling the mechanics of partially mineralized collagen fibrils, fibres and tissue
Y Liu, S Thomopoulos, C Chen… - Journal of the …, 2014 - royalsocietypublishing.org
Progressive stiffening of collagen tissue by bioapatite mineral is important physiologically,
but the details of this stiffening are uncertain. Unresolved questions about the details of the …
but the details of this stiffening are uncertain. Unresolved questions about the details of the …
Mechanical behavior of hydroxyapatite biomaterials: an experimentally validated micromechanical model for elasticity and strength
A Fritsch, L Dormieux, C Hellmich… - Journal of Biomedical …, 2009 - Wiley Online Library
Hydroxyapatite (HA) biomaterials production has been a major field in biomaterials science
and biomechanical engineering. As concerns prediction of their stiffness and strength, we …
and biomechanical engineering. As concerns prediction of their stiffness and strength, we …
Multi-scale modelling of elastic moduli of trabecular bone
We model trabecular bone as a nanocomposite material with hierarchical structure and
predict its elastic properties at different structural scales. The analysis involves a bottom-up …
predict its elastic properties at different structural scales. The analysis involves a bottom-up …
Mechanical testing of bones: the positive synergy of finite–element models and in vitro experiments
Bone biomechanics have been extensively investigated in the past both with in vitro
experiments and numerical models. In most cases either approach is chosen, without …
experiments and numerical models. In most cases either approach is chosen, without …
Recent advances on the measurement and calculation of the elastic moduli of cortical and trabecular bone: a review
In this review, recent advances on the measurement and modeling of elastic properties of
cortical and trabecular bone are presented. Bone is a multifunctional material which among …
cortical and trabecular bone are presented. Bone is a multifunctional material which among …
In silico assessment of biomedical products: the conundrum of rare but not so rare events in two case studies
M Viceconti, C Cobelli, T Haddad… - Proceedings of the …, 2017 - journals.sagepub.com
In silico clinical trials, defined as “The use of individualized computer simulation in the
development or regulatory evaluation of a medicinal product, medical device, or medical …
development or regulatory evaluation of a medicinal product, medical device, or medical …
Bone and its adaptation to mechanical loading: a review
Bone is a remarkable living material that comes in two forms with different porosities and
different macrostructure, but with the same highly organised microstructure and …
different macrostructure, but with the same highly organised microstructure and …
Mechanics of molecular collagen is influenced by hydroxyapatite in natural bone
As often seen in biological structural materials, bone exhibits complex hierarchical structure.
The primary constituents of bone are collagen and hydroxyapatite (HAP). HAP mineralizes …
The primary constituents of bone are collagen and hydroxyapatite (HAP). HAP mineralizes …
Elastic moduli of untreated, demineralized and deproteinized cortical bone: validation of a theoretical model of bone as an interpenetrating composite material
A theoretical experimentally based multi-scale model of the elastic response of cortical bone
is presented. It portrays the hierarchical structure of bone as a composite with …
is presented. It portrays the hierarchical structure of bone as a composite with …
Three-dimensional biomechanical modeling of cylindrical bone-like porous materials subject to acoustic waves
This paper describes a three-dimensional (3D) analytical solution for the acoustic response
of cancellous bone-like porous materials saturated with a viscous fluid. The effect of dynamic …
of cancellous bone-like porous materials saturated with a viscous fluid. The effect of dynamic …