Bone diseases such as rickets and osteoporosis cause significant reduction in bone quantity
and quality, which leads to mechanical abnormalities. However, the precise ultrastructural …

It is well known that hydration of collagenous tissues leads to their swelling, as well as to
softening of their elastic behavior. However, it is much less clear which microstructural and …

In this study, the homogenized anisotropic elastic properties of single bone lamellae are
computed using a finite element unit cell method. The resulting stiffness tensor is utilized to …

Data from bone drying, demineralization, and deorganification tests, collected over a time
span of more than 80 years, evidence a myriad of different chemical compositions of …

The voxel finite cell method uses unfitted finite element meshes and voxel quadrature rules
to seamlessly transfer computed tomography data into patient‐specific bone discretizations …

A micromechanical multiscale model which estimates the elastic properties of cortical bone
as a function of porosity and mineral content is presented. The steps of the model are …

Bone is a connective tissue which gives body its support and stability. In mechanical terms,
bone is a nanocomposite material with a complex hierarchical structure which contributes to …

Mesoscale modeling is often considered merely as a practical strategy used when
information on lower-scale details is lacking, or when there is a need to make models …

There is growing experimental evidence for non‐affine deformations occurring in different
types of fibrous soft tissues; meaning that the fiber orientations do not follow the macroscopic …

Denosumab, a fully human monoclonal antibody, has been approved for the treatment of
postmenopausal osteoporosis. The therapeutic effect of denosumab rests on its ability to …