Receptor tyrosine kinase signaling and targeting in glioblastoma multiforme
Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …
Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging
IO Flores, S Treviño, A Díaz - Neural Regeneration Research, 2023 - journals.lww.com
Aging is a global phenomenon and a complex biological process of all living beings that
introduces various changes. During this physiological process, the brain is the most affected …
introduces various changes. During this physiological process, the brain is the most affected …
SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma
X Zhang, H Zhang, Z Liao, J Zhang, H Liang… - Cancer Cell …, 2022 - Springer
Abstract Background The Src homology and collagen 4 (SHC4) is an important intracellular
adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma …
adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma …
Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion
Gliomas are characterized by diffuse infiltration of tumor cells into surrounding brain tissue,
and this highly invasive nature contributes to disease recurrence and poor patient outcomes …
and this highly invasive nature contributes to disease recurrence and poor patient outcomes …
Deletion of p66Shc Dysregulates ERK and STAT3 Activity in Mouse Embryonic Stem Cells, Enhancing Their Naive-Like Self-Renewal in the Presence of Leukemia …
AM Powell, NA Edwards, H Hunter, P Kiser… - Stem Cells and …, 2023 - liebertpub.com
The ShcA adapter protein is necessary for early embryonic development. The role of ShcA in
development is primarily attributed to its 52 and 46 kDa isoforms that transduce receptor …
development is primarily attributed to its 52 and 46 kDa isoforms that transduce receptor …
The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking
Shc family signalling adaptors connect activated transmembrane receptors to proximal
effectors, and most also contain a sequence involved in clathrin-mediated receptor …
effectors, and most also contain a sequence involved in clathrin-mediated receptor …
Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system
HN Robeson, HR Lau, LA New, J Lalonde… - BMC neuroscience, 2019 - Springer
Abstract Background Mammalian Shc (Src homology and collagen) proteins comprise a
family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal …
family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal …