[HTML][HTML] Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

[HTML][HTML] Molecular basic of pharmacotherapy of cytokine imbalance as a component of intervertebral disc degeneration treatment

NA Shnayder, AV Ashkhotov, VV Trefilova… - International Journal of …, 2023 - mdpi.com
Intervertebral disc degeneration (IDD) and associated conditions are an important problem
in modern medicine. The onset of IDD may be in childhood and adolescence in patients with …

[HTML][HTML] The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis

EV Ivarsdottir, H Holm, S Benonisdottir… - Communications …, 2021 - nature.com
Age-related hearing impairment (ARHI) is the most common sensory disorder in older
adults. We conducted a genome-wide association meta-analysis of 121,934 ARHI cases …

Gender-based occupational segregation and sex differences in sensory, motor, and spatial aptitudes

M Baker, K Cornelson - Demography, 2018 - read.dukeupress.edu
Research on sex differences in humans documents gender differences in sensory, motor,
and spatial aptitudes. These aptitudes, as captured by Dictionary of Occupational Titles …

[HTML][HTML] The role of insulin-like growth factor 1 in the progression of age-related hearing loss

L RodriGuez-De La Rosa, L Lassaletta… - Frontiers in Aging …, 2017 - frontiersin.org
Aging is associated with impairment of sensorial functions and with the onset of
neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) …

[HTML][HTML] A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice

R Riquelme, R Cediel, J Contreras… - Frontiers in …, 2010 - frontiersin.org
Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a
key role during the late development of the nervous system. Human IGF1 mutations cause …

[HTML][HTML] The role of insulin-like growth factor-I in the physiopathology of hearing

S Murillo-Cuesta, L Rodríguez-de La Rosa… - Frontiers in molecular …, 2011 - frontiersin.org
Insulin-like growth factor-I (IGF-I) belongs to the family of polypeptides of insulin, which play
a central role in embryonic development and adult nervous system homeostasis by …

Clinical study on 136 children with sudden sensorineural hearing loss

FJ Li, DY Wang, HY Wang, L Wang, FB Yang… - Chinese Medical …, 2016 - mednexus.org
Background: The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is
consistently increasing. However, the pathology and prognosis of CSSNHL are still poorly …

Electrochemical impedimetric immunosensor for insulin like growth factor-1 using specific monoclonal antibody-nanogold modified electrode

B Rezaei, N Majidi, H Rahmani, T Khayamian - Biosensors and …, 2011 - Elsevier
An electrochemical impedimetric immunosensor was developed for ultrasensitive
determination of insulin-like growth factor-1 (IGF-1) based on immobilization of a specific …

[PDF][PDF] IGF-I deficiency and hearing loss: molecular clues and clinical implications

I Varela-Nieto, S Murillo-Cuesta… - Pediatr Endocrinol …, 2013 - researchgate.net
Sensorineural hearing loss is a clinical heterogeneous disorder and a significant health-
care problem with tremendous socio-economic impact. According to WHO,“Over 5% of the …