Primary membranous nephropathy

WG Couser - Clinical Journal of the American Society of …, 2017 - journals.lww.com
Membranous nephropathy (MN) is a unique glomerular lesion that is the most common
cause of idiopathic nephrotic syndrome in nondiabetic white adults. About 80% of cases are …

Environmental pollution and kidney diseases

X Xu, S Nie, H Ding, FF Hou - Nature Reviews Nephrology, 2018 - nature.com
The burden of disease and death attributable to environmental pollution is becoming a
public health challenge worldwide, especially in developing countries. The kidney is …

Membranous nephropathy

P Ronco, L Beck, H Debiec, FC Fervenza… - Nature reviews Disease …, 2021 - nature.com
Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults,
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …

[HTML][HTML] The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery

AE van de Logt, M Fresquet, JF Wetzels, P Brenchley - Kidney international, 2019 - Elsevier
The discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary
target in membranous nephropathy (MN) greatly advanced basic and clinical research …

PLA2R and THSD7A: disparate paths to the same disease?

LH Beck Jr - Journal of the American Society of Nephrology, 2017 - journals.lww.com
The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A
(THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and …

Mechanisms of primary membranous nephropathy

Y Gu, H Xu, D Tang - Biomolecules, 2021 - mdpi.com
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and
one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous …

Detection of PLA2R autoantibodies before the diagnosis of membranous nephropathy

PD Burbelo, M Joshi, A Chaturvedi… - Journal of the …, 2020 - journals.lww.com
Background Circulating serum autoantibodies against the M-type phospholipase A2
receptor (PLA2R-AB) are a key biomarker in the diagnosis and monitoring of primary …

Molecular pathogenesis of membranous nephropathy

P Ronco, H Debiec - Annual Review of Pathology: Mechanisms …, 2020 - annualreviews.org
Membranous nephropathy is a noninflammatory autoimmune disease of the kidney
glomerulus, characterized by the formation of immune deposits, complement-mediated …

Single-cell profiling reveals transcriptional signatures and cell-cell crosstalk in anti-PLA2R positive idiopathic membranous nephropathy patients

J Xu, C Shen, W Lin, T Meng, JD Ooi… - Frontiers in …, 2021 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

HLA and kidney disease: from associations to mechanisms

KJ Robson, JD Ooi, SR Holdsworth… - Nature Reviews …, 2018 - nature.com
Since the first association between HLA and diseases of native kidneys was described
almost 50 years ago, technological and conceptual advances in HLA biology and typing …