[PDF][PDF] Defining human tyrosine kinase phosphorylation networks using yeast as an in vivo model substrate

T Corwin, J Woodsmith, F Apelt, JF Fontaine… - Cell systems, 2017 - cell.com
Systematic assessment of tyrosine kinase-substrate relationships is fundamental to a better
understanding of cellular signaling and its profound alterations in human diseases such as …

[HTML][HTML] Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich

F Iorio, L Garcia-Alonso, JS Brammeld… - Scientific reports, 2018 - nature.com
Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively
characterised, the way these traits are achieved through the accumulation of somatic …

[HTML][HTML] Transcriptional network architecture of breast cancer molecular subtypes

G de Anda-Jáuregui, TE Velázquez-Caldelas… - Frontiers in …, 2016 - frontiersin.org
Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High
throughput technologies allowed the identification of intrinsic subtypes that capture …

Experimental identification of cancer driver alterations in the era of pan‐cancer genomics

M Korenjak, J Zavadil - Cancer science, 2019 - Wiley Online Library
Rapidly accumulating data from large‐scale cancer genomics studies have been generating
important information about genes and their somatic alterations underlying cell …

[HTML][HTML] Graphlet eigencentralities capture novel central roles of genes in pathways

SFL Windels, N Malod-Dognin, N Pržulj - Plos one, 2022 - journals.plos.org
Motivation Graphlet adjacency extends regular node adjacency in a network by considering
a pair of nodes being adjacent if they participate in a given graphlet (small, connected …

[HTML][HTML] Quantification of ferroptosis pathway status revealed heterogeneity in breast cancer patients with distinct immune microenvironment

Y Li, T Li, D Zhai, C Xie, X Kuang, Y Lin… - Frontiers in …, 2022 - frontiersin.org
Clinical significance and biological functions of the ferroptosis pathway were addressed in
all aspect of cancer regarding multi-omics level, however, the overall status of ferroptosis …

Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS‐CoV‐2 and a Multitude of Pathological Viruses In Vitro

PR Raghavan - BioMed research international, 2022 - Wiley Online Library
Increasing outbreaks of new pathogenic viruses have promoted the exploration of novel
alternatives to time‐consuming vaccines. Thus, it is necessary to develop a universal …

[HTML][HTML] Analysis of the TCGA dataset reveals that subsites of laryngeal squamous cell carcinoma are molecularly distinct

A Sorgini, HAJ Kim, PYF Zeng, MH Shaikh, N Mundi… - Cancers, 2020 - mdpi.com
Simple Summary Squamous cell carcinomas from different parts of the larynx have distinct
presentations and prognoses, but the molecular basis for this discrepancy has yet to be …

[HTML][HTML] Performance assessment of the network reconstruction approaches on various interactomes

MK Arici, N Tuncbag - Frontiers in molecular biosciences, 2021 - frontiersin.org
The single omic data type is not capable of fully representing cellular activity. Additionally,
individual entities do not behave isolated but rather function synergistically or may not be …

Incorporating pathway information into feature selection towards better performed gene signatures

S Tian, C Wang, B Wang - BioMed research international, 2019 - Wiley Online Library
To analyze gene expression data with sophisticated grouping structures and to extract
hidden patterns from such data, feature selection is of critical importance. It is well known …