[PDF][PDF] Defining human tyrosine kinase phosphorylation networks using yeast as an in vivo model substrate
Systematic assessment of tyrosine kinase-substrate relationships is fundamental to a better
understanding of cellular signaling and its profound alterations in human diseases such as …
understanding of cellular signaling and its profound alterations in human diseases such as …
[HTML][HTML] Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich
Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively
characterised, the way these traits are achieved through the accumulation of somatic …
characterised, the way these traits are achieved through the accumulation of somatic …
[HTML][HTML] Transcriptional network architecture of breast cancer molecular subtypes
G de Anda-Jáuregui, TE Velázquez-Caldelas… - Frontiers in …, 2016 - frontiersin.org
Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High
throughput technologies allowed the identification of intrinsic subtypes that capture …
throughput technologies allowed the identification of intrinsic subtypes that capture …
Experimental identification of cancer driver alterations in the era of pan‐cancer genomics
M Korenjak, J Zavadil - Cancer science, 2019 - Wiley Online Library
Rapidly accumulating data from large‐scale cancer genomics studies have been generating
important information about genes and their somatic alterations underlying cell …
important information about genes and their somatic alterations underlying cell …
[HTML][HTML] Graphlet eigencentralities capture novel central roles of genes in pathways
Motivation Graphlet adjacency extends regular node adjacency in a network by considering
a pair of nodes being adjacent if they participate in a given graphlet (small, connected …
a pair of nodes being adjacent if they participate in a given graphlet (small, connected …
[HTML][HTML] Quantification of ferroptosis pathway status revealed heterogeneity in breast cancer patients with distinct immune microenvironment
Y Li, T Li, D Zhai, C Xie, X Kuang, Y Lin… - Frontiers in …, 2022 - frontiersin.org
Clinical significance and biological functions of the ferroptosis pathway were addressed in
all aspect of cancer regarding multi-omics level, however, the overall status of ferroptosis …
all aspect of cancer regarding multi-omics level, however, the overall status of ferroptosis …
Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS‐CoV‐2 and a Multitude of Pathological Viruses In Vitro
PR Raghavan - BioMed research international, 2022 - Wiley Online Library
Increasing outbreaks of new pathogenic viruses have promoted the exploration of novel
alternatives to time‐consuming vaccines. Thus, it is necessary to develop a universal …
alternatives to time‐consuming vaccines. Thus, it is necessary to develop a universal …
[HTML][HTML] Analysis of the TCGA dataset reveals that subsites of laryngeal squamous cell carcinoma are molecularly distinct
Simple Summary Squamous cell carcinomas from different parts of the larynx have distinct
presentations and prognoses, but the molecular basis for this discrepancy has yet to be …
presentations and prognoses, but the molecular basis for this discrepancy has yet to be …
[HTML][HTML] Performance assessment of the network reconstruction approaches on various interactomes
The single omic data type is not capable of fully representing cellular activity. Additionally,
individual entities do not behave isolated but rather function synergistically or may not be …
individual entities do not behave isolated but rather function synergistically or may not be …
Incorporating pathway information into feature selection towards better performed gene signatures
S Tian, C Wang, B Wang - BioMed research international, 2019 - Wiley Online Library
To analyze gene expression data with sophisticated grouping structures and to extract
hidden patterns from such data, feature selection is of critical importance. It is well known …
hidden patterns from such data, feature selection is of critical importance. It is well known …