Algorithms for active module identification (AMI) are central to analysis of omics data. Such
algorithms receive a gene network and nodes' activity scores as input and report …

Intratumor heterogeneity (ITH) is observed at different stages of tumor progression,
metastasis and reouccurence, which can be important for clinical applications. We used …

Cancer is a complex disease in which unrestrained cell proliferation results in tumour
development. Extensive research into the molecular mechanisms underlying tumorigenesis …

This study was designed to investigate at the molecular level how a transgenic version of
rice “Nipponbare” obtained a drought-resistant phenotype. Using multi-omics sequencing …

Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat
expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the …

Pathway analysis methods are frequently applied to cancer gene expression data to identify
dysregulated pathways. These methods often infer pathway activity based on the expression …

Motivation Network propagation has been widely used to aggregate and amplify the effects
of tumor mutations using knowledge of molecular interaction networks. However …

Background Protein interaction databases often provide confidence scores for each
recorded interaction based on the available experimental evidence. Protein interaction …

A complex and vast biological network regulates all biological functions in the human body
in a sophisticated manner, and abnormalities in this network can lead to disease and even …

Rapid assessment and intervention of suicide risk are common and challenging in
psychiatric emergency departments (PED). It is unclear whether distinct pathophysiological …