Motivation Functional enrichment testing methods can reduce data comprising hundreds of
altered biomolecules to smaller sets of altered biological 'concepts' that help generate …

Characterizing cellular responses to different extrinsic signals is an active area of research,
and curated pathway databases describe these complex signaling reactions. Here, we …

Genome wide association studies (GWAS) of human diseases have generally identified
many loci associated with risk with relatively small effect sizes. The omnigenic model …

Cervical cancer is one of the most prevalent gynecologic malignancies and has remained
an intractable cancer over the past decades. We analyzed the aberrant expression patterns …

While the primary sequences of human proteins have been cataloged for over a decade,
determining how these are organized into a dynamic collection of multiprotein assemblies …

The drug therapy for non-small cell lung cancer (NSCLC) have always been issues of
poisonous side effect, acquired drug resistance and narrow applicable population. In this …

Background Recent efforts in the field of nutritional science have allowed the discovery of
disease-beating molecules within foods based on the commonality of bioactive food …

Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism
appear to be related to complications from multiple diseases, including type 2 diabetes …

It has been almost 15 years since the first microarray-based studies creating multigene
biomarkers to subtype and predict survival of cancer patients. This Perspective looks at why …

Background Cancer is increasingly recognized as a cellular system phenomenon that is
attributed to the accumulation of genetic or epigenetic alterations leading to the perturbation …