Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Inflammatory bowel diseases (IBD) arise from a convergence of genetic risk, environmental
factors, and gut microbiota, where each is necessary but not sufficient to cause disease …

Environmental factors, mucosal permeability and defective immunoregulation drive
overactive immunity to a subset of resident intestinal bacteria that mediate multiple …

The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery
of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a …

Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also
controls immune-mediated skin responses. The AHR modulates various physiological …

The biological mechanisms involved in SARS-CoV-2 infection are only partially understood.
Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search …

Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical
manifestations of joint inflammation, bone damage and cartilage destruction, joint …

Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the
host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that …

The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-
spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan …