Obstructive sleep apnea (OSA) is a highly prevalent disorder that has profound implications
on the outcomes of patients with chronic lung disease. The hallmark of OSA is a collapse of …

This review explores forms of respiratory and autonomic plasticity, and associated outcome
measures, that are initiated by exposure to intermittent hypoxia. The review focuses primarily …

Ever since their origin more than one half-century ago, microneurographic recordings of
sympathetic nerve activity have significantly advanced our understanding of the generation …

Key points Ventilatory long‐term facilitation (vLTF) refers to respiratory neuroplasticity that
develops following intermittent hypoxia in both healthy and clinical populations. A sustained …

The present paper will provide an update on the role of sympathetic neural factors in the
development and progression of essential hypertension by reviewing data collected in the …

Acute intermittent hypoxia (AIH) elicits long‐term facilitation (LTF) of respiration. Although
LTF is observed when CO2 is elevated during AIH in awake humans, the influence of CO2 …

Repetitive hypoxic apneas, similar to those observed in sleep apnea, result in resetting of
the sympathetic baroreflex to higher blood pressures (BP). This baroreflex resetting is …

Augmented blood pressure variability has emerged as a quantity predictive of adverse
cardiovascular outcomes. Among the range of intrinsic and extrinsic factors shown to …

We examined the effect of acute intermittent hypoxia (IH) on sympathetic neural firing
patterns and the role of the carotid chemoreceptors. We hypothesized exposure to acute IH …

Post‐hypoxia sympathoexcitation does not elicit corresponding changes in vascular tone,
suggesting diminished sympathetic signalling. Blunted sympathetic transduction following …