Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease
J Zhu, H Yang, Y Chen, H Lin, Q Li, J Mo… - Journal of Enzyme …, 2018 - Taylor & Francis
The cholinergic hypothesis has long been a “polar star” in drug discovery for Alzheimer's
disease (AD), resulting in many small molecules and biological drug candidates. Most of the …
disease (AD), resulting in many small molecules and biological drug candidates. Most of the …
Identification of embelin, a 3‐undecyl‐1,4‐benzoquinone from Embelia ribes as a multitargeted anti‐Alzheimer agent
Abstract Beta‐secreatse (BACE‐1) and cholinesterases are clinically validated targets of
Alzheimer's disease (AD), for which natural products have provided immense contribution …
Alzheimer's disease (AD), for which natural products have provided immense contribution …
[HTML][HTML] Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer's disease
A Pasieka, D Panek, P Zaręba, E Sługocka… - Bioorganic & Medicinal …, 2023 - Elsevier
Butyrylcholinesterase (BuChE) and amyloid β (Aβ) aggregation remain important biological
target and mechanism in the search for effective treatment of Alzheimer's disease …
target and mechanism in the search for effective treatment of Alzheimer's disease …
Protective effects of caffeic acid and the alzheimer's brain: an update
S Habtemariam - Mini reviews in medicinal chemistry, 2017 - ingentaconnect.com
Background: Caffeic acid (CA) and related phenylpropanoic acids are ubiquitous natural
products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl …
products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl …
[HTML][HTML] Dihydropyrimidinone-derived selenoesters efficacy and safety in an in vivo model of Aβ aggregation
FS de Oliveira Pereira, FAR Barbosa, RFS Canto… - Neurotoxicology, 2022 - Elsevier
In a previous in vitro study, dihydropyrimidinone-derived selenoesteres demonstrated
antioxidant properties, metal chelators and inhibitory acetylcholinesterase (AChE) activity …
antioxidant properties, metal chelators and inhibitory acetylcholinesterase (AChE) activity …
Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors
Abstract Indole based thiadiazole derivatives (1–18) were synthesized and evaluated for
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …
A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase 1
ZM Liu, L Feng, GB Ge, X Lv, J Hou, YF Cao… - Biosensors and …, 2014 - Elsevier
A new ratiometric fluorescent probe derived from 2-(2-hydroxy-3-methoxyphenyl)
benzothiazole (HMBT) has been developed for selective monitoring of human …
benzothiazole (HMBT) has been developed for selective monitoring of human …
The design of novel 4, 6-dimethoxyindole based hydrazide-hydrazones: Molecular modeling, synthesis and anticholinesterase activity
Abstract Biologically important hydrazide-hydrazone (–(C= O) NHN= CH) functionality was
located at two different positions on 4, 6-dimethoxyindole moiety and novel compounds 11a …
located at two different positions on 4, 6-dimethoxyindole moiety and novel compounds 11a …
Synthesis, biological evaluation and molecular docking study of oxindole based chalcone analogues as potent anti-Alzheimer agents
With the goal of developing potential cholinesterase pharmaco-therapeutics, a new class of
thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted …
thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted …
[HTML][HTML] New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential …
GF Makhaeva, NV Kovaleva, NP Boltneva… - Molecules, 2020 - mdpi.com
New hybrid compounds of 4-amino-2, 3-polymethylene-quinoline containing different sizes
of the aliphatic ring and linked to p-tolylsulfonamide with alkylene spacers of increasing …
of the aliphatic ring and linked to p-tolylsulfonamide with alkylene spacers of increasing …