As an effective and versatile strategy to compartmentalize cellular components without the
need for lipid membranes, phase separation has been found to underpin a wide range of …

Genetic information is stored in very long DNA molecules, which are folded to form
chromatin, a similarly long polymer fibre that is ultimately organised into chromosomes. The …

The unprecedented non-reproducibility of the results published in the field of cancer
research has recently come under the spotlight. In this short review, we try to highlight some …

The dynamics of DNA in the cell nucleus plays a role in cellular processes and fates but the
interplay of DNA mobility with the hierarchical levels of DNA organization is still …

Chromatin has been shown to undergo diffusional motion, which is affected during gene
transcription by RNA polymerase activity. However, the relationship between chromatin …

Recently, biomolecular condensates formed through liquid–liquid phase separation have
been widely reported to regulate key intracellular processes involved in cell biology and …

Recent advances chromatin capture, imaging techniques, and polymer modeling have
dramatically enhanced quantitative understanding of chromosomal folding. However, the …

The article reviews the development of ideas on the domain organization of eukaryotic
genome, with special attention on the studies of DNA loops anchored to the nuclear matrix …

ASARs are a family of very-long noncoding RNAs that control replication timing on individual
human autosomes, and are essential for chromosome stability. The eight known ASAR …

Recent chromatin capture, imaging techniques, and polymer modeling advancements have
dramatically enhanced our quantitative understanding of chromosomal folding. However …