Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress-induced social avoidance and anxiety-like behaviors in male rats
Rationale Exposure to traumatic events can lead to alterations in social and anxiety-related
behaviors. Emerging evidence suggests that peripheral host-defense processes are …
behaviors. Emerging evidence suggests that peripheral host-defense processes are …
Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder
Background and aim Post-traumatic stress disorder (PTSD), a chronic debilitating condition
that affects nearly 5–10% of American adults, is treated with a handful of FDA-approved …
that affects nearly 5–10% of American adults, is treated with a handful of FDA-approved …
[HTML][HTML] Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
S Nobili, L Micheli, E Lucarini, A Toti… - Pharmacology & …, 2024 - Elsevier
Current epidemiological data estimate that one in five people suffers from chronic pain with
considerable impairment of health-related quality of life. The pharmacological treatment is …
considerable impairment of health-related quality of life. The pharmacological treatment is …
Lysosome targeting fluorescent probe for NAAA imaging and its applications in the drug development for anti-inflammatory
L Zhou, M Tian, B Zhang, X Cao, X Huo, F Yang… - International Journal of …, 2024 - Elsevier
N-acylethanolamine acid amidase (NAAA) is a nucleophilic lysosomal cysteine hydrolase,
which primarily mediates the hydrolytic inactivation of endogenous palmitoylethanolamide …
which primarily mediates the hydrolytic inactivation of endogenous palmitoylethanolamide …
α-Acylamino-β-lactone N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and …
N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that
preferentially catalyzes the hydrolysis of endogenous lipid mediators such as …
preferentially catalyzes the hydrolysis of endogenous lipid mediators such as …
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice
Y Fotio, A Mabou Tagne, E Squire, H Lee… - Nature …, 2024 - nature.com
Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …
Genetic blockade of NAAA cell-specifically regulates fatty acid ethanolamides (FAEs) metabolism and inflammatory responses
N-Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme responsible for the
hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs …
hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs …
Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition
The intracellular lipid amidases, fatty acid amide hydrolase (FAAH) and N-acylethanolamine
acid amidase (NAAA), terminate the actions of anandamide and palmitoylethanolamide …
acid amidase (NAAA), terminate the actions of anandamide and palmitoylethanolamide …