Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

K Du, X Li, C Zheng, L Lai, M Shen, Y Wang… - Bioorganic Chemistry, 2023 - Elsevier
Four monoterpenoid indole alkaloid dimers (MIADs), axidimins AD (1–4), which possesses
unprecedented apidosperma-aspidosperma-type skeletons, along with twelve known MIAs …

[PDF][PDF] A REVIEW ON INDOLO [2, 3-a] QUINOLIZIDINE: THE SYNTHETIC APPROACHES TO THE DEVELOPMENT OF BIOACTIVE INDOLO [2, 3-a] QUINOLIZIDINE …

S Sharma, Y Monga, A Gupta, S Singh - Heterocycles, 2023 - researchgate.net
Tetracyclic indolo [2, 3-a] quinolizidine motifs are an important class of molecules in
research and development due to their wide spectrum of biological activities, which include …

Ormosianines A–P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis

Q Jin, XJ Qin, WJ Sun, X Ding, Y Zhao… - Journal of Natural …, 2023 - ACS Publications
Sixteen new quinolizidine alkaloids (QAs), named ormosianines A–P (1–16), and 18 known
congeners (17–34) were isolated from the stems and leaves of Ormosia yunnanensis. The …

Splicing Indoles and 4,5-Dihydro-1H-pyrazoline Structure Gave Birth to Novel Antiviral Agents: Design, Synthesis, and Mechanism Study

L Bai, C Wei, Z Shen, H He, X Yang, S Shi… - Journal of Agricultural …, 2023 - ACS Publications
The specific conation of our research is to invent a series of indole derivatives containing a
4, 5-dihydro-1 H-pyrazoline motif with effective antiviral activity. The anti-potato virus Y (PVY) …

Applications of Nuclear Magnetic Resonance Spectroscopy to Traditional Chinese Medicine

L Wang, Y Zhu, L Yun, Y Guo, Y Pan… - Natural Product …, 2023 - journals.sagepub.com
Background In recent years, the focus of traditional Chinese medicine (TCM) research has
gradually shifted from pure chemical research to looking at the combination of chemistry with …

Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylation

C Chen, JW Liu, LL Guo, F Xiong, XQ Ran, YR Guo… - Phytochemistry, 2022 - Elsevier
Three undescribed monoterpenoid indole alkaloid dimers (kopoffines AC, which are
connected via a methylene unit) and with nine known alkaloids were isolated and identified …

New steroidal alkaloids with anti-inflammatory and analgesic effects from Veratrum grandiflorum

TZ Xie, YL Zhao, H Wang, YC Chen, X Wei… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance “Li-Lu”, the roots and rhizomes of Veratrum
grandiflorum (Melianthiaceae), has been historically used as a traditional folk medicine for …

Novel indole alkaloids from Rauvolfia yunnanensis, inhibiting ESBL producing Escherichia coli by targeting cell membrane integrity

ML Qin, W Gao, H Wu, HF Yu, WY Hu, CF Xiao… - Tetrahedron …, 2023 - Elsevier
Three unique monoterpenoid indole alkaloids, raufiayunesins AC (1–3) were obtained from
the leaves of Rauvolfia yunnanensis. 1 and 2 were the rare spiro monoterpenoid indole …

[HTML][HTML] The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation

Y Liao, JY Wang, Y Pan, X Zou, C Wang, Y Peng… - Molecules, 2023 - mdpi.com
Here,(-)-Tetrahydroalstonine (THA) was isolated from Alstonia scholaris and investigated for
its neuroprotective effect towards oxygen–glucose deprivation/re-oxygenation (OGD/R) …

[HTML][HTML] Evaluation of comparative chemical profiling and bioactivities of medicinal and non-medicinal parts of Ampelopsis delavayana

J Qiong, H Yang, Y Xie, P Zhu, G Chen, Q Zhou… - Heliyon, 2024 - cell.com
Ampelopsis delavayana, a distinctive Yi medicine, utilized the roots as an essential
medicinal substance for trauma treatment of the" Yunnan Hong Yao". A. delavayana …