Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

BJ Benedikter, EFM Wouters… - Journal of Toxicology …, 2018 - Taylor & Francis
Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological
processes when released in response to cellular stresses. Respiratory exposures such as …

Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review

L Morin, V Lecureur, A Lescoat - Particle and Fibre Toxicology, 2024 - Springer
Background Crystalline silica (cSiO2) is a mineral found in rocks; workers from the
construction or denim industries are particularly exposed to cSiO2 through inhalation. cSiO2 …

Transcriptome profile analysis reveals a silica-induced immune response and fibrosis in a silicosis rat model

H Zhao, Z Jiang, R Lv, X Li, Y Xing, Y Gao, D Lv, Y Si… - Toxicology letters, 2020 - Elsevier
Silicosis is a type of pneumoconiosis caused by the inhalation of silica dust. It is
characterized by inflammation and fibrosis of the lung. Although many studies have reported …

Identification of a Gene Signature Predicting (Nano) Particle-Induced Adverse Lung Outcome in Rats

SA Valentino, C Seidel, M Lorcin, S Sébillaud… - International Journal of …, 2023 - mdpi.com
Nanoparticles are extensively used in industrial products or as food additives. However,
despite their contribution to improving our quality of life, concerns have been raised …

The oxidative stress-dependent pulmonary inflammation of inhalable multi-walled carbon nanotube-containing nano-concrete dust and its comparison with …

E Bae, S Kim, JH Sung, JH Kim, SH Jung… - Journal of Hazardous …, 2024 - Elsevier
Nano-concrete, which is an admixture of nanomaterials in concrete recipes, has been
investigated to overcome the limitations of existing concrete, such as its stability and …

Induction of chromosomal damage in exfoliated buccal and nasal cells of road markers

G Wultsch, A Nersesyan, M Kundi… - Journal of Toxicology …, 2019 - Taylor & Francis
Road markers are exposed to various chemicals and particles. The aim of this study was to
determine whether road worker exposure induceschromosomal damage which is indicative …

A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity

HI Warheit‐Niemi, EM Hult… - Clinical & Translational …, 2019 - Wiley Online Library
Lung fibrosis is characterised by the accumulation of extracellular matrix within the lung and
is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits …

Telomeres in toxicology: Occupational health

M Shoeb, HCS Meier, JM Antonini - Pharmacology & therapeutics, 2021 - Elsevier
The ends of chromosomes shorten at each round of cell division, and this process is thought
to be affected by occupational exposures. Occupational hazards may alter telomere length …

Short-term pulmonary toxicity assessment of pre-and post-incinerated organomodified nanoclay in mice

TA Stueckle, DC Davidson, R Derk, TG Kornberg… - ACS …, 2018 - ACS Publications
Organomodified nanoclays (ONCs) are increasingly used as filler materials to improve
nanocomposite strength, wettability, flammability, and durability. However, pulmonary risks …

Protective effect of Paeoniae radix alba root extract on immune alterations in mice with atopic dermatitis

GH Jo, SN Kim, MJ Kim, Y Heo - Journal of Toxicology and …, 2018 - Taylor & Francis
Atopic dermatitis is a progressive inflammatory disease characterized by type 2 helper T cell
(TH2) reactivity. The aim of this study was to examine the therapeutic effects of Paeoniae …