iPS-cell technology and the problem of genetic instability—Can it ever be safe for clinical use?

SW Attwood, MJ Edel - Journal of clinical medicine, 2019 - mdpi.com
The use of induced Pluripotent Stem Cells (iPSC) as a source of autologous tissues shows
great promise in regenerative medicine. Nevertheless, several major challenges remain to …

Pluripotent stem cells from domesticated mammals

T Ezashi, Y Yuan, RM Roberts - Annual review of animal …, 2016 - annualreviews.org
This review deals with the latest advances in the study of embryonic stem cells (ESC) and
induced pluripotent stem cells (iPSC) from domesticated species, with a focus on pigs, cattle …

Derivation and characterization of bovine induced pluripotent stem cells by transposon-mediated reprogramming

TR Talluri, D Kumar, S Glage, W Garrels… - … " Cloning and Stem …, 2015 - liebertpub.com
Induced pluripotent stem cells (iPSCs) are a seminal breakthrough in stem cell research and
are promising tools for advanced regenerative therapies in humans and reproductive …

Use of gene-editing technology to introduce targeted modifications in pigs

J Ryu, RS Prather, K Lee - Journal of animal science and biotechnology, 2018 - Springer
Pigs are an important resource in agriculture and serve as a model for human diseases. Due
to their physiological and anatomical similarities with humans, pigs can recapitulate …

Derivation of sheep embryonic stem cells under optimized conditions

M Vilarino, DA Soto, YS Bogliotti, L Yu, Y Zhang… - …, 2020 - rep.bioscientifica.com
Until recently, it has been difficult to derive and maintain stable embryonic stem cells lines
from livestock species. Sheep ESCs with characteristics similar to those described for …

Generation of induced pluripotent stem cells from large domestic animals

FF Bressan, V Bassanezze… - Stem Cell Research & …, 2020 - Springer
Background Induced pluripotent stem cells (iPSCs) have enormous potential in
developmental biology studies and in cellular therapies. Although extensively studied and …

Stem cells-derived in vitro meat: from petri dish to dinner plate

A Singh, V Verma, M Kumar, A Kumar… - Critical reviews in …, 2022 - Taylor & Francis
Sustainable food supply to the world is possibly the greatest challenge that human
civilization has ever faced. Among animal sourced foods, meat plays a starring role in …

Pluripotent stem cells and livestock genetic engineering

DA Soto, PJ Ross - Transgenic research, 2016 - Springer
The unlimited proliferative ability and capacity to contribute to germline chimeras make
pluripotent embryonic stem cells (ESCs) perfect candidates for complex genetic …

[HTML][HTML] Perspectives of pluripotent stem cells in livestock

D Kumar, TR Talluri, NL Selokar, I Hyder… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
The recent progress in derivation of pluripotent stem cells (PSCs) from farm animals opens
new approaches not only for reproduction, genetic engineering, treatment and conservation …

Livestock models for exploiting the promise of pluripotent stem cells

RM Roberts, Y Yuan, N Genovese, T Ezashi - ILAR journal, 2015 - academic.oup.com
Livestock species are widely used as biomedical models. Pigs, in particular, are beginning
to have a significant role in regenerative medicine for testing the applicability, success, and …