Introduction: The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of
cell growth, cell development and the differentiation of normal stem cells. Constitutive …

RNA interference (RNAi) is a phenomenon of sequence-specific gene silencing in
mammalian cells and its discovery has lead to its wide application as a powerful tool in post …

Tumor initiation is driven by oncogenes that activate signaling networks for cell proliferation
and survival involving protein phosphorylation. Protein kinases in these pathways have …

Research in cognitive psychology focused on risk perception and decision making was
shown to facilitate treatment choice and patient's satisfaction with decision in a number of …

Bisphosphonates (BPs) are inhibitors of bone-resorption and have become the current
standard of care for preventing skeletal complications associated with bone metastases …

BACKGROUND Despite advances in drug therapy and allogeneic stem cell transplantation
(allo‐SCT), the prognosis of patients with chronic myeloid leukemia (CML) in blast crisis …

Alternative approaches for inhibitor development in targeting sites other than the ATP cleft
are increasingly being pursued in the search for new therapeutics based on inhibition of …

Bcr-Abl tyrosine kinase (TK) inhibitors are promising therapeutic agents for Bcr-Abl-positive
(Bcr-Abl+) leukemias. Although they are known to promote caspase-mediated apoptosis, it …

The concept of leukemic stem cells (LSC) is increasingly employed to explain the biology of
various myeloid neoplasms and to screen for essential targets, with the hope to improve …

Background Superficial bladder cancers are usually managed with transurethral resection
followed by the intravesical administration of Bacillus Calmette-Guerin which requires major …