The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Genetics of bipolar disorder
N Craddock, P Sklar - The Lancet, 2013 - thelancet.com
Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
It is well established that autism spectrum disorders (ASD) have a strong genetic
component; however, for at least 70% of cases, the underlying genetic cause is unknown …
component; however, for at least 70% of cases, the underlying genetic cause is unknown …
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Nature genetics, 2011 - nature.com
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …
Stress signalling pathways that impair prefrontal cortex structure and function
AFT Arnsten - Nature reviews neuroscience, 2009 - nature.com
The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Abstract Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the
action of multiple genetic and environmental risk factors. We report the findings of a genome …
action of multiple genetic and environmental risk factors. We report the findings of a genome …
Circadian rhythm in bipolar disorder: a review of the literature
Y Takaesu - Psychiatry and clinical neurosciences, 2018 - Wiley Online Library
Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in
patients with bipolar disorder (BD). Irregularity of the sleep–wake rhythm, eveningness …
patients with bipolar disorder (BD). Irregularity of the sleep–wake rhythm, eveningness …
Genome-wide association study reveals two new risk loci for bipolar disorder
TW Mühleisen, M Leber, TG Schulze… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …
association studies (GWAS) have robustly identified the first common genetic variants …