Governed by parasite and host factors and immunoinflammatory responses, the clinical
spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions) …

Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

The obligate intracellular parasite Leishmania must survive the antimicrobial activities of its
host cell, the macrophage, and prevent activation of an effective immune response. In order …

▪ Abstract Cytokines are an integral component of the adaptive and innate immune
responses. The signaling pathways triggered by the engagement of cytokines with their …

Leishmania major is an obligate intracellular eukaryotic pathogen of mononuclear
phagocytes. Invasive promastigotes gain entry into target cells by receptor‐mediated …

Leishmania parasites are the causative agents of the leishmaniases, a collection of vector-
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …

Leptin, a pleiotropic protein has long been recognized to play an important role in the
regulation of energy homeostasis, metabolism, neuroendocrine function, and other …

Experimental visceral leishmaniasis (VL) caused by infection with Leishmania donovani
results in the development of organ‐specific immunity in the two main target tissues of …

Cytokine signaling is dependent on the activation of intracellular molecules, including JAKs
(Janus family kinases) and STATs (signal transducers and activators of transcription). Since …

Many infectious diseases are associated with parasite persistence, often restricted to certain
tissue sites, yet the determinants of such persistence are poorly understood. Infection with …