A review on exosomes application in clinical trials: perspective, questions, and challenges
Background Exosomes are progressively known as significant mediators of cell-to-cell
communication. They convey active biomolecules to target cells and have vital functions in …
communication. They convey active biomolecules to target cells and have vital functions in …
Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …
applications in various diseases. These natural nanoparticles benefit from favorable safety …
Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …
[HTML][HTML] Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue
Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …
Non-viral vectors for RNA delivery
Y Yan, XY Liu, A Lu, XY Wang, LX Jiang… - Journal of Controlled …, 2022 - Elsevier
RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …
The cellular response to extracellular vesicles is dependent on their cell source and dose
Extracellular vesicles (EVs) have been established to play important roles in cell-cell
communication and shown promise as therapeutic agents. However, we still lack a basic …
communication and shown promise as therapeutic agents. However, we still lack a basic …
Extracellular vesicles: a rising star for therapeutics and drug delivery
S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …
Current knowledge on exosome biogenesis, cargo-sorting mechanism and therapeutic implications
S Xie, Q Zhang, L Jiang - Membranes, 2022 - mdpi.com
Extracellular vesicles (EVs) are nanoscale membrane vesicles released by donor cells that
can be taken up by recipient cells. The study of EVs has the potential to identify unknown …
can be taken up by recipient cells. The study of EVs has the potential to identify unknown …
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases
Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …
Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx
W Zheng, R He, X Liang, S Roudi, J Bost… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical
and biological drugs. However, their efficacy is limited by the lack of cellular specificity …
and biological drugs. However, their efficacy is limited by the lack of cellular specificity …