Sphingolipids as critical players in retinal physiology and pathology
MV Simon, SK Basu, B Qaladize, R Grambergs… - Journal of lipid …, 2021 - ASBMB
Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …
physiological and pathological processes. In the retina, they have been established to …
Beyond VEGF: targeting inflammation and other pathways for treatment of retinal disease
A Muniyandi, GD Hartman, Y Song, M Mijit… - … of Pharmacology and …, 2023 - ASPET
Neovascular eye diseases include conditions such as retinopathy of prematurity,
proliferative diabetic retinopathy, and neovascular age-related macular degeneration …
proliferative diabetic retinopathy, and neovascular age-related macular degeneration …
Hydroxychloroquine causes early inner retinal toxicity and affects autophagosome–lysosomal pathway and sphingolipid metabolism in the retina
Hydroxychloroquine (HCQ) is an anti-malarial drug but also widely used to treat
autoimmune diseases like arthritis and lupus. Although there have been multiple reports of …
autoimmune diseases like arthritis and lupus. Although there have been multiple reports of …
The role of sphingolipids in meibomian gland dysfunction and ocular surface inflammation
Inflammation occurs in response to tissue injury and invasion of microorganisms and is
carried out by the innate and adaptive immune systems, which are regulated by numerous …
carried out by the innate and adaptive immune systems, which are regulated by numerous …
Sphingosine-1-phosphate and ceramide-1-phosphate promote migration, pro-inflammatory and pro-fibrotic responses in retinal pigment epithelium cells
MV Simón, MS Vera, PE Tenconi, T Soto… - Experimental Eye …, 2022 - Elsevier
Retinal pigment epithelium (RPE) cells, essential for preserving retina homeostasis, also
contribute to the development of retina proliferative diseases, through their exacerbated …
contribute to the development of retina proliferative diseases, through their exacerbated …
Exploring the molecular mechanism of Qing Guang an granule in treating glaucoma using network pharmacology and molecular docking
C Ou, H Song, Y Zhou, J Peng… - … and Alternative Medicine, 2020 - Wiley Online Library
Background. Qing Guang An Granule (QGAG), a Chinese patent medicine, has been used
clinically to treat glaucoma for more than 20 years. Objective. To explore the possible …
clinically to treat glaucoma for more than 20 years. Objective. To explore the possible …
AOP and IATA applied to ocular surface toxicity
N Bonneau, C Baudouin… - Regulatory Toxicology and …, 2021 - Elsevier
Until now, the Draize test on rabbits has been the only test performed to anticipate ocular
toxicity of pharmaceutical compounds, mainly irritation. The OECD is urging the scientific …
toxicity of pharmaceutical compounds, mainly irritation. The OECD is urging the scientific …
[HTML][HTML] Human stem cell-derived retinal pigment epithelial cells as a model for drug screening and pre-clinical assays compared to ARPE-19 cell line
CR Oliveira, MRB de Paiva… - … Journal of Stem …, 2021 - synapse.koreamed.org
Methods and Results Functional, cellular and molecular data obtained suggest that hES-
RPE cells more closely resembles native RPEs compared to ARPE-19. Furthermore, hES …
RPE cells more closely resembles native RPEs compared to ARPE-19. Furthermore, hES …
A comprehensive profiling of cellular sphingolipids in mammalian endothelial and microglial cells cultured in normal and high-glucose conditions
Sphingolipids (SPLs) play a diverse role in maintaining cellular homeostasis. Dysregulated
SPL metabolism is associated with pathological changes in stressed and diseased cells …
SPL metabolism is associated with pathological changes in stressed and diseased cells …
[HTML][HTML] Using the TCGA database to predict and analyze tumor microenvironment genes related to poor prognosis of colon cancer
S Chen, L Yida, B Chen, MM Xiong - Medical science monitor …, 2020 - ncbi.nlm.nih.gov
Background Colon cancer (COAD) is a highly malignant gastrointestinal cancer. The
existence of the TCGA database allows us to more easily perform gene expression profiling …
existence of the TCGA database allows us to more easily perform gene expression profiling …