Cancer stem cells (CSCs), which comprise a small fraction of cancer cells, are believed to
constitute the origin of most human tumors. Considerable effort has been focused on …

Considering the complexity of the current framework in oncology, the relevance of animal
models in biomedical research is critical in light of the capacity to produce valuable data with …

Macrophages, which are abundant in the tumour microenvironment, enhance malignancy.
At metastatic sites, a distinct population of metastasis-associated macrophages promotes …

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In
the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) …

HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large
proportion of solid tumor metastases are bone metastases, known to usurp HSC homing …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Increasing evidence points towards a causal link between exposure to persistent organic
pollutants (POPs) with increased incidence and aggressivity of various cancers. Among …

Cancer metastasis is a multistep process associated with the induction of an epithelial-
mesenchymal transition (EMT) and cancer stem cells (CSCs). Although significant progress …

One of the most life‐threatening complications of prostate cancer is skeletal metastasis. In
order to develop treatment for metastasis, it is important to understand its molecular …

Disseminated tumor cells (DTCs) are believed to lie dormant in the marrow before they can
be activated to form metastases. How DTCs become dormant in the marrow and how …