Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment

S Lombardo, U Maskos - Neuropharmacology, 2015 - Elsevier
Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

[HTML][HTML] Alzheimer's disease as a membrane disorder: Spatial cross-talk among beta-amyloid peptides, nicotinic acetylcholine receptors and lipid rafts

C Fabiani, SS Antollini - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's …

G Cui, H Guo, H Li, Y Zhai, Z Gong, J Wu, J Liu… - Immunity & …, 2019 - Springer
Background Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer
functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived …

Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

Why people see things that are not there: a novel perception and attention deficit model for recurrent complex visual hallucinations

D Collerton, E Perry, I McKeith - Behavioral and Brain Sciences, 2005 - cambridge.org
As many as two million people in the United Kingdom repeatedly see people, animals, and
objects that have no objective reality. Hallucinations on the border of sleep, dementing …

Cognitive effects of nicotine

AH Rezvani, ED Levin - Biological psychiatry, 2001 - Elsevier
Nicotine and other nicotinic agonists have been found to improve performance on attention
and memory tasks. Clinical studies using nicotine skin patches have demonstrated the …

Nicotinic acetylcholine involvement in cognitive function in animals

ED Levin, BB Simon - Psychopharmacology, 1998 - Springer
Nicotinic cholinergic systems are involved with several important aspects of cognitive
function including attention, learning and memory. Nicotinic cholinergic receptors are …

[图书][B] The epidemiology of dementia and Alzheimer's disease

C Kawas, R Katzman - 1994 - escholarship.org
Our understanding of the epidemiology of Alzheimer disease (AD) has advanced rapidly
during the past decade. Community (population) studies in many countries have confirmed …

Oxidative stress: free radical production in neural degeneration

ME Götz, G Künig, P Riederer, MBH Youdim - Pharmacology & therapeutics, 1994 - Elsevier
It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

Nicotinic systems and cognitive function

ED Levin - Psychopharmacology, 1992 - Springer
Nicotinic acetylcholine receptors have been found to be important for maintaining optimal
performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of …