Aged Long-Evans rats (24–25 months old) were classified into cognitively impaired or
unimpaired subgroups based on their performances in the Morris Swim Maze task …

Purposes We present the first in-human brain PET imaging data of the new α4β2 nicotinic
acetylcholine receptor (nAChR)–targeting radioligand (+)-[18 F] Flubatine. Aims were to …

The present study investigated the effects of amyloid-β peptides on nicotinic ACh receptors
(Torpedo, α4β2, and α7 receptors) and AMPA receptors expressed in Xenopus oocytes by …

The adult spontaneously hypertensive rat (SHR) has been shown to exhibit a decrease in
the expression and nicotine-stimulated function of brain nicotinic acetylcholine receptors …

The effects of the muscarinic antagonist scopolamine (0.1–0.6 mg/kg, IP) and the nicotinic
antagonist mecamylamine (1–10 mg/kg) were compared in T-maze alternation and …

Alzheimer's disease and inclusion body myositis (IBM) are disorders frequently found in the
elderly and characterized by the presence of amyloid-β peptide (Aβ) aggregates. We used C …

Dichotomizing perceptions, by those that have an objective reality and those that do not, is
rejected. Perceptions are suggested to fall along a multidimensional continuum in which …

Cigarette smoking, and by implication nicotine, may be involved as a negative or positive
risk factor in some neuropsychiatric disorders and possibly as a treatment in others. Nicotine …

In addition to S (−)-nicotine, several minor tobacco alkaloids ((±)-nornicotine, anabaseine, S
(−)-anabasine, and S (−)-N-methylanabasine) are present in tobacco smoke. This study …

In this review, we outline the role of the cholinergic system in Huntington's disease, and
briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic …