[HTML][HTML] OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives

L Sánchez-Puebla, I López-Cuenca, E Salobrar-García… - Biomedicines, 2024 - mdpi.com
The murine models of Alzheimer's disease (AD) have advanced our understanding of the
pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

[HTML][HTML] Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status

H Shi, N Mirzaei, Y Koronyo, MR Davis… - Acta …, 2024 - Springer
This study investigates various pathological tau isoforms in the retina of individuals with
early and advanced Alzheimer's disease (AD), exploring their connection with disease …

Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop

EY Chew, SA Burns, AG Abraham… - Nature Reviews …, 2024 - nature.com
The accessibility of the retina with the use of non-invasive and relatively low-cost ophthalmic
imaging techniques and analytics provides a unique opportunity to improve the detection …

[HTML][HTML] Outer Retinal Thickness Is Associated With Cognitive Function in Normal Aging to Intermediate Age-Related Macular Degeneration

C Owsley, G McGwin, TA Swain… - … & Visual Science, 2024 - tvst.arvojournals.org
Purpose: Research on Alzheimer's disease (AD) and precursor states demonstrates a
thinner retinal nerve fiber layer (NFL) compared to age-similar controls. Because AD and …

Choriocapillaris reduction accurately discriminates against early‐onset Alzheimer's disease

WR Kwapong, F Tang, P Liu, Z Zhang… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION This study addresses the urgent need for non‐invasive early‐onset
Alzheimer's disease (EOAD) prediction. Using optical coherence tomography angiography …

[HTML][HTML] Genetic context modulates aging and degeneration in the murine retina

OJ Marola, M MacLean, TL Cossette, CA Diemler… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Background: Age is the principal risk factor for neurodegeneration in both the retina and
brain. The retina and brain share many biological properties; thus, insights into retinal aging …

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia

LX Tan, FC Oertel, A Cheng, Y Cobigo, A Keihani… - bioRxiv, 2024 - biorxiv.org
Mutations in progranulin (GRN) cause frontotemporal dementia (GRN-FTD) due to
deficiency of the pleiotropic protein progranulin. GRN-FTD exhibits diverse pathologies …

OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives

L Sánchez-Puebla Fernández, I López Cuenca… - 2024 - docta.ucm.es
The murine models of Alzheimer's disease (AD) have advanced our understanding of the
pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) …

[PDF][PDF] HISTOLOGICAL EXAMINATION OF RETINAL FUNCTION AND THE EFFECTS OF CURCUMA LONGA ON MEMORY CORRECTION IN EXPERIMENTAL …

U Gashimova, R Guliyeva, K Javadova… - … in Biology & Earth …, 2024 - jomardpublishing.com
According to the latest literature data, histological studies of the retina in animal models of
experimental Alzheimer's disease prove invaluable for identifying the disease in its early …