Characterization of mismatch‐repair/microsatellite instability‐discordant endometrial cancers
Abstract Background Mismatch‐repair (MMR)/microsatellite instability (MSI) status has
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …
Insulin-like growth factor 2 (IGF2) signaling in colorectal cancer—from basic research to potential clinical applications
A Kasprzak, A Adamek - International journal of molecular sciences, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common cancers in men and women worldwide
as well as is the leading cause of death in the western world. Almost a third of the patients …
as well as is the leading cause of death in the western world. Almost a third of the patients …
Associations of pathogenic variants in MLH1, MSH2, and MSH6 with risk of colorectal adenomas and tumors and with somatic mutations in patients with Lynch …
C Engel, A Ahadova, TT Seppälä, S Aretz… - Gastroenterology, 2020 - Elsevier
Background & Aims Lynch syndrome is caused by variants in DNA mismatch repair (MMR)
genes and associated with an increased risk of colorectal cancer (CRC). In patients with …
genes and associated with an increased risk of colorectal cancer (CRC). In patients with …
[HTML][HTML] Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response
Q Qin, Y Zhou, J Guo, Q Chen, W Tang, Y Li, J You… - Genome Medicine, 2024 - Springer
Background Aberrant DNA methylation is a major characteristic of cancer genomes. It
remains unclear which biological processes determine epigenetic reprogramming and how …
remains unclear which biological processes determine epigenetic reprogramming and how …
From genetics to histomolecular characterization: an insight into colorectal carcinogenesis in lynch syndrome
M Lepore Signorile, V Disciglio, G Di Carlo… - International journal of …, 2021 - mdpi.com
Lynch syndrome is a hereditary cancer-predisposing syndrome caused by germline defects
in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. Carriers of …
in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. Carriers of …
Onco-preventive and chemo-protective effects of apple bioactive compounds
Cancer is one of the leading causes of death globally. Epidemiological studies have strongly
linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research …
linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research …
Microsatellite instability: a review of molecular epidemiology and implications for immune checkpoint inhibitor therapy
A Kavun, E Veselovsky, A Lebedeva, E Belova… - Cancers, 2023 - mdpi.com
Simple Summary Microsatellite instability (MSI) occurs in a wide variety of tumor types and is
one of the most important predictive biomarkers for immune checkpoint inhibitor therapy …
one of the most important predictive biomarkers for immune checkpoint inhibitor therapy …
Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis
C Perne, S Peters, M Cartolano, S Horpaopan… - PLoS …, 2021 - journals.plos.org
The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic
pathogenic germline variants in the MSH3 gene, was comprehensively analysed to …
pathogenic germline variants in the MSH3 gene, was comprehensively analysed to …
Comprehensive analysis of the potential biological significance of cuproptosis-related gene LIPT2 in pan-cancer prognosis and immunotherapy
W Wang, S Li, Y Huang, J Guo, L Sun, G Sun - Scientific Reports, 2023 - nature.com
Abstract Lipoyltransferase 2 (LIPT2) acts as a key enzyme involved in fatty acid metabolism
and cell membrane synthesis. However, the biological function of LIPT2 in various cancer …
and cell membrane synthesis. However, the biological function of LIPT2 in various cancer …
[HTML][HTML] Does breast carcinoma belong to the Lynch syndrome tumor spectrum?–Somatic mutational profiles vs. ovarian and colorectal carcinomas
NK Porkka, A Olkinuora, T Kuopio, M Ahtiainen… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Inherited DNA mismatch repair (MMR) defects cause predisposition to colorectal,
endometrial, ovarian, and other cancers occurring in Lynch syndrome (LS). It is unsettled …
endometrial, ovarian, and other cancers occurring in Lynch syndrome (LS). It is unsettled …