Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …

Discovery of the enzymatic activity that catalyses oxidation of 5-methylcytosine (5mC) to
generate 5-hydroxymethylcytosine (5hmC) mediated by the MLL (KMT2A) fusion partner …

Background The DNA methylation profiles of mammalian cell lines differ from those of the
primary tissues from which they were derived, exhibiting increasing divergence from the in …

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

Abstract The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic
oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is …

Epigenetic control of gene expression programs is essential for normal organismal
development and cellular function. Abrogation of epigenetic regulation is seen in many …

DNA methylation at the 5-position of cytosine (5mC) is an epigenetic modification that
regulates gene expression and cellular plasticity in development and disease. The ten …

The patterns of DNA methylation in human cancer cells are highly abnormal and often
involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands …

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at
repressed genes in the host tissue, but the preceding events driving this phenomenon are …

Abstract The 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification whose role in
the pathogenesis of metabolic-related complex diseases remains unexplored; 5-hmC …