Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and have
diverse functions during development and organogenesis. BMPs play a major role in …

Endothelial‐to‐mesenchymal transition (EndMT) has been unveiled as a common cause for
a multitude of human pathologies, including cancer and cardiovascular disease. Vascular …

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
family, are multifunctional cytokines. BMPs have a broad range of functions, and …

Bone morphogenetic proteins (BMPs) and their receptors, known to be essential regulators
of embryonic patterning and organogenesis, are also critical for the regulation of …

Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …

Introduction: The transforming growth factor-β (TGF-β) signaling pathway has a pivotal role
in tumor suppression and yet, paradoxically, in tumor promotion. Functional context …

The vascular system is critical for developmental growth, tissue homeostasis and repair but
also for tumor development. Bone morphogenetic protein (BMP) signaling has recently …