Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They
are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have …

Cancer is a major cause of death worldwide, with an increasing number of cases being
reported annually. The elevated rate of mortality necessitates a global challenge to explore …

Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are
essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin …

Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

Background—Inflammatory processes have been identified as key mediators of the
deleterious effects of ischemia/reperfusion in ST-segment–elevation myocardial infarction …

Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …

Microtubule-targeting agents are widely used for the treatment of cancer and as tool
compounds to study the microtubule cytoskeleton. BAL27862 is a novel microtubule …

Eukaryotic flagella and cilia are built on a 9+ 2 array of microtubules plus> 250 accessory
proteins, forming a biological machine called the axoneme. Here we describe the three …

Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of chemotherapy
that is frequently experienced by patients receiving treatment for cancer. CIPN is caused by …