Adipokines, adiposity, and atherosclerosis

L Liu, Z Shi, X Ji, W Zhang, J Luan, T Zahr… - Cellular and Molecular …, 2022 - Springer
Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …

The role of cytokines in the development of atherosclerosis

AR Fatkhullina, IO Peshkova, EK Koltsova - Biochemistry (Moscow), 2016 - Springer
Atherosclerosis contributes to the development of many cardiovascular diseases, which
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …

Immunobiology of atherosclerosis: a complex net of interactions

B Herrero-Fernandez, R Gomez-Bris… - International Journal of …, 2019 - mdpi.com
Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

Inflammation and immune system interactions in atherosclerosis

B Legein, L Temmerman, EAL Biessen… - Cellular and Molecular …, 2013 - Springer
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for
16.7 million deaths each year. The underlying cause of the majority of CVD is …

Cytokines and atherosclerosis: a comprehensive review of studies in mice

R Kleemann, S Zadelaar, T Kooistra - Cardiovascular research, 2008 - academic.oup.com
In the past few years, inflammation has emerged as a major driving force of atherosclerotic
lesion development. It is now well-established that from early lesion to vulnerable plaque …

Adaptive immunity and atherosclerosis

J Andersson, P Libby, GK Hansson - Clinical immunology, 2010 - Elsevier
Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most
common causes of death globally. It has been evident for more than 20 years that adaptive …

T cells in atherogenesis: for better or for worse?

AKL Robertson, GK Hansson - Arteriosclerosis, thrombosis, and …, 2006 - Am Heart Assoc
The idea that atherosclerosis is an inflammatory disease is no longer controversial. Instead,
much of the current research is now focused on understanding what drives this inflammation …

NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology

A Manea - Cell and tissue research, 2010 - Springer
Reactive oxygen species (ROS) are essential mediators of normal cell physiology. However,
in the last few decades, it has become evident that ROS overproduction and/or alterations of …

Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor AI/II

S Kuchibhotla, D Vanegas, DJ Kennedy… - Cardiovascular …, 2008 - academic.oup.com
Aims The role of scavenger receptors in atherogenesis is controversial as a result of
conflicting reports and a recent hypothesis suggesting that scavenger receptor absence …

Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential

C Spitz, H Winkels, C Bürger, C Weber… - Cellular and molecular …, 2016 - Springer
Atherosclerosis is a chronic inflammatory disease that is mediated by innate and adaptive
immune responses. The disease is characterized by sub-endothelial accumulation and …