Sleep homeostasis and circadian function are important maintaining factors for optimal
health and well-being. Conversely, sleep and circadian disruptions are implicated in a …

Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

Although research has identified dozens of behavioral and psychosocial strategies for
boosting resilience in adults, little is known about the common underlying pathways. A …

Modern life poses many threats to good-quality sleep, challenging brain health across the
lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence …

The prefrontal cortex (PFC) is considered to constitute the highest stage of neural integration
and to be devoted to representation and production of actions. Studies in primates have laid …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

Disrupted sleep is a symptom of many psychiatric disorders, including substance use
disorders. Most drugs of abuse, including opioids, disrupt sleep. However, the extent and …

Reducing sleep hours is a risk factor for developing cardiovascular, metabolic, and
psychiatric disorders. Furthermore, previous studies have shown that reduction in sleep time …

Severe and persistent disruptions to sleep and circadian rhythms are common in people
with opioid use disorder (OUD). Preclinical evidence suggests altered molecular rhythms in …

Previous research has shown that acute sleep deprivation can influence the reward
networks. However, it is unclear whether and how the intrinsic reward network is altered in …